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Article

Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

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Biomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
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Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Kosice, Slovakia
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Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
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Department of Biophysics, Faculty of Science, Palacky University Olomouc, Krizkovskeho 511/8, CZ-779 00 Olomouc, Czech Republic
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(12), 2468; https://doi.org/10.3390/nano10122468
Received: 18 November 2020 / Revised: 30 November 2020 / Accepted: 7 December 2020 / Published: 9 December 2020
Dextran-coated magnetic nanoparticles are promising biocompatible agents in various biomedical applications, including hyperthermia and magnetic resonance imaging (MRI). However, the influence of dextran molecular weight on the physical properties of dextran-coated magnetic nanoparticles has not been described sufficiently. We synthesise magnetite nanoparticles with a dextran coating using a co-precipitation method and study their physical properties as a function of dextran molecular weight. Several different methods are used to determine the size distribution of the particles, including microscopy, dynamic light scattering, differential centrifugal sedimentation and magnetic measurements. The size of the dextran-coated particles increases with increasing dextran molecular weight. We find that the molecular weight of dextran has a significant effect on the particle size, efficiency, magnetic properties and specific absorption rate. Magnetic hyperthermia measurements show that heating is faster for dextran-coated particles with higher molecular weight. The different molecular weights of the coating also significantly affected its MRI relaxation properties, especially the transversal relaxivity r2. Linear regression analysis reveals a statistically significant dependence of r2 on the differential centrifugal sedimentation diameter. This allows the targeted preparation of dextran-coated magnetic nanoparticles with the desired MRI properties. These results will aid the development of functionalised magnetic nanoparticles for hyperthermia and MRI applications. View Full-Text
Keywords: magnetic fluid; magnetic nanoparticles; dextran; physical properties; diameter; magnetic hyperthermia; MRI; relaxivity magnetic fluid; magnetic nanoparticles; dextran; physical properties; diameter; magnetic hyperthermia; MRI; relaxivity
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MDPI and ACS Style

Strbak, O.; Antal, I.; Khmara, I.; Koneracka, M.; Kubovcikova, M.; Zavisova, V.; Molcan, M.; Jurikova, A.; Hnilicova, P.; Gombos, J.; Kadasova, N.; Dobrota, D. Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications. Nanomaterials 2020, 10, 2468. https://doi.org/10.3390/nano10122468

AMA Style

Strbak O, Antal I, Khmara I, Koneracka M, Kubovcikova M, Zavisova V, Molcan M, Jurikova A, Hnilicova P, Gombos J, Kadasova N, Dobrota D. Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications. Nanomaterials. 2020; 10(12):2468. https://doi.org/10.3390/nano10122468

Chicago/Turabian Style

Strbak, Oliver, Iryna Antal, Iryna Khmara, Martina Koneracka, Martina Kubovcikova, Vlasta Zavisova, Matus Molcan, Alena Jurikova, Petra Hnilicova, Jan Gombos, Nina Kadasova, and Dusan Dobrota. 2020. "Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications" Nanomaterials 10, no. 12: 2468. https://doi.org/10.3390/nano10122468

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