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Article

Hydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery

1
IBMM, Univ Montpellier, CNRS, ENSCM, 34093 Montpellier, France
2
Department of Biochemistry, Medical Research Institute, University of Alexandria, Alexandria 21561, Egypt
*
Authors to whom correspondence should be addressed.
Present address: IRMB, CARTIGEN, CHU de Montpellier, 34090 Montpellier, France.
These authors contributed equally to this work.
Nanomaterials 2020, 10(12), 2334; https://doi.org/10.3390/nano10122334
Received: 16 October 2020 / Revised: 9 November 2020 / Accepted: 21 November 2020 / Published: 25 November 2020
(This article belongs to the Special Issue Nano-Scale Gene Delivery Systems)
Small interfering RNAs (siRNAs) are promising molecules for developing new therapies based on gene silencing; however, their delivery into cells remains an issue. In this study, we took advantage of stapled peptide technology that has emerged as a valuable strategy to render natural peptides more structured, resistant to protease degradation and more bioavailable, to develop short carriers for siRNA delivery. From the pool of stapled peptides that we have designed and synthesized, we identified non-toxic vectors that were able to efficiently encapsulate siRNA, transport them into the cell and induce gene silencing. Remarkably, the most efficient stapled peptide (JMV6582), is composed of only eight amino-acids and contains only two cationic charges. View Full-Text
Keywords: CPP; Stapled peptides; siRNA; gene silencing CPP; Stapled peptides; siRNA; gene silencing
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MDPI and ACS Style

Simon, M.; Laroui, N.; Heyraud, M.; Laconde, G.; Ali, L.M.A.; Bourbiaux, K.; Subra, G.; Vezenkov, L.L.; Legrand, B.; Amblard, M.; Bettache, N. Hydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery. Nanomaterials 2020, 10, 2334. https://doi.org/10.3390/nano10122334

AMA Style

Simon M, Laroui N, Heyraud M, Laconde G, Ali LMA, Bourbiaux K, Subra G, Vezenkov LL, Legrand B, Amblard M, Bettache N. Hydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery. Nanomaterials. 2020; 10(12):2334. https://doi.org/10.3390/nano10122334

Chicago/Turabian Style

Simon, Matthieu, Nabila Laroui, Marianne Heyraud, Guillaume Laconde, Lamiaa M.A. Ali, Kevin Bourbiaux, Gilles Subra, Lubomir L. Vezenkov, Baptiste Legrand, Muriel Amblard, and Nadir Bettache. 2020. "Hydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery" Nanomaterials 10, no. 12: 2334. https://doi.org/10.3390/nano10122334

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