Next Article in Journal
Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
Next Article in Special Issue
Transcatheter Decellularized Tissue-Engineered Heart Valve (dTEHV) Grown on Polyglycolic Acid (PGA) Scaffold Coated with P4HB Shows Improved Functionality over 52 Weeks due to Polyether-Ether-Ketone (PEEK) Insert
Previous Article in Journal
An In Vitro Model for Assessing Corneal Keratocyte Spreading and Migration on Aligned Fibrillar Collagen
Previous Article in Special Issue
Specialized Living Wound Dressing Based on the Self-Assembly Approach of Tissue Engineering
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessArticle

Evaluation of Antibiotic-Releasing Triphasic Bone Void Filler In-Vitro

Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA
Northside Hospital System, Atlanta, GA 30342, USA
Division of Orthopaedics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2018, 9(4), 55;
Received: 31 July 2018 / Revised: 31 August 2018 / Accepted: 17 September 2018 / Published: 21 September 2018
(This article belongs to the Special Issue Biomaterial Enhanced Regeneration)
PDF [542 KB, uploaded 21 September 2018]


Bone void fillers (BVFs) containing calcium sulfate, tricalcium phosphate (TCP), and hydroxyapatite can be loaded with antibiotics for infection treatment or prevention under surgeon-directed use. The aim of this study was to characterize the handling and elution properties of a triphasic BVF loaded with common antibiotics. BVF was mixed with vancomycin and/or tobramycin to form pellets, and the set time was recorded. A partial refreshment elution study was conducted with time points at 4, 8, and 24 h, as well as 2, 7, 14, 28, and 42 days. Effects on dissolution were evaluated in a 14-day dissolution study. Set time increased to over 1 h for groups containing tobramycin, although vancomycin had a minimal effect. Pellets continued to elute antibiotics throughout the 42-day elution study, suggesting efficacy for the treatment or prevention of orthopedic infections. BVF containing vancomycin or tobramycin showed similar dissolution at 14 days compared to BVF without antibiotics; however, BVF containing both antibiotics showed significantly more dissolution. View Full-Text
Keywords: bone void filler; calcium composites; infection bone void filler; calcium composites; infection

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Harris, M.; Ahmed, H.; Pace, L.; Minter, J.; Neel, M.; Jennings, J. Evaluation of Antibiotic-Releasing Triphasic Bone Void Filler In-Vitro. J. Funct. Biomater. 2018, 9, 55.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top