Next Article in Journal / Special Issue
DNA-Based Single-Molecule Electronics: From Concept to Function
Previous Article in Journal / Special Issue
Methods to Improve Osseointegration of Dental Implants in Low Quality (Type-IV) Bone: An Overview
Open AccessFeature PaperReview

Calcium Phosphates as Delivery Systems for Bisphosphonates

Department of Chemistry “G. Ciamician”, University of Bologna, 40126 Bologna, Italy
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2018, 9(1), 6; https://doi.org/10.3390/jfb9010006
Received: 19 December 2017 / Revised: 8 January 2018 / Accepted: 11 January 2018 / Published: 13 January 2018
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
Bisphosphonates (BPs) are the most utilized drugs for the treatment of osteoporosis, and are usefully employed also for other pathologies characterized by abnormally high bone resorption, including bone metastases. Due to the great affinity of these drugs for calcium ions, calcium phosphates are ideal delivery systems for local administration of BPs to bone, which is aimed to avoid/limit the undesirable side effects of their prolonged systemic use. Direct synthesis in aqueous medium and chemisorptions from solution are the two main routes proposed to synthesize BP functionalized calcium phosphates. The present review overviews the information acquired through the studies on the interaction between bisphosphonate molecules and calcium phosphates. Moreover, particular attention is addressed to some important recent achievements on the applications of BP functionalized calcium phosphates as biomaterials for bone substitution/repair. View Full-Text
Keywords: hydroxyapatite; bisphosphonates; octacalcium phosphate; β-tricalcium phosphate; functionalization; alendronate; zoledronate hydroxyapatite; bisphosphonates; octacalcium phosphate; β-tricalcium phosphate; functionalization; alendronate; zoledronate
Show Figures

Figure 1

MDPI and ACS Style

Bigi, A.; Boanini, E. Calcium Phosphates as Delivery Systems for Bisphosphonates. J. Funct. Biomater. 2018, 9, 6.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop