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J. Funct. Biomater. 2018, 9(1), 12; https://doi.org/10.3390/jfb9010012

Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum

1
Sydney Medical School, The University of Sydney, Sydney 2006, Australia
2
Medlab Clinical, Sydney 2015, Australia
*
Author to whom correspondence should be addressed.
Received: 23 December 2017 / Revised: 16 January 2018 / Accepted: 18 January 2018 / Published: 21 January 2018
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Abstract

The administration of biological compounds that optimize health benefits is an ever-evolving therapeutic goal. Pharmaceutical and other adjunctive biological compounds have been administered via many different routes in order to produce a systemic pharmacological effect. The article summarizes the findings from an Australian comparative study in adults administered vitamin B12 through different oral delivery platforms. A total of 16 subjects (9 males, 7 females) voluntarily partook in a comparative clinical study of five different vitamin B12 formulations across a six-month period, completing 474 person-hours of cumulative contribution, that was equivalent to an n = 60 participation. A nanoparticle delivered vitamin B12 through a NanoCelle platform was observed to be significantly (p < 0.05) better absorbed than all other dose equivalent platforms (i.e., tablets, emulsions, or liposomes) from baseline to 1, 3, and 6 h of the study period. The nanoparticle platform delivered vitamin B12 demonstrated an enhanced and significant absorption profile as exemplified by rapid systemic detection (i.e., 1 h from baseline) when administered to the oro-buccal mucosa with no reports of any adverse events of toxicity. The nanoparticle formulation of methylcobalamin (1000 µg/dose in 0.3 mL volume) showed bioequivalence only with a chewable-dissolvable tablet that administered a five times higher dose of methylcobalamin (5000 µg) per tablet. This study has demonstrated that an active metabolite embedded in a functional biomaterial (NanoCelle) may constitute a drug delivery method that can better access the circulatory system. View Full-Text
Keywords: nanoparticles; NanoCelle; vitamin B12; methylcobalamin; cyanocobalamin; liposome; emulsion; tablets nanoparticles; NanoCelle; vitamin B12; methylcobalamin; cyanocobalamin; liposome; emulsion; tablets
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Vitetta, L.; Zhou, J.; Manuel, R.; Dal Forno, S.; Hall, S.; Rutolo, D. Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum. J. Funct. Biomater. 2018, 9, 12.

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