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J. Funct. Biomater. 2016, 7(3), 27;

Synthesis and Characterization of Nanodiamond Reinforced Chitosan for Bone Tissue Engineering

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada
Author to whom correspondence should be addressed.
Academic Editor: Xuebin Yang
Received: 26 April 2016 / Revised: 17 August 2016 / Accepted: 22 August 2016 / Published: 15 September 2016
(This article belongs to the Special Issue Mechanical Properties of Tissue Engineering Scaffolds)
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Multifunctional tissue scaffold material nanodiamond (ND)/chitosan (CS) composites with different diamond concentrations from 1 wt % to 5 wt % were synthesized through a solution casting method. The microstructure and mechanical properties of the composites were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and nanoindentation. Compared with pristine CS, the addition of ND resulted in a significant improvement of mechanical properties, including a 239%, 276%, 321%, 333%, and 343% increase in Young’s modulus and a 68%, 96%, 114%, 118%, and 127% increase in hardness when the ND amount was 1 wt %, 2 wt %, 3 wt %, 4 wt %, and 5 wt %, respectively. The strong interaction between ND surface groups and the chitosan matrix plays an important role in improving mechanical properties. View Full-Text
Keywords: nanodiamond; chitosan; scaffold; nanoindentation; DSC; MTT nanodiamond; chitosan; scaffold; nanoindentation; DSC; MTT

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Sun, Y.; Yang, Q.; Wang, H. Synthesis and Characterization of Nanodiamond Reinforced Chitosan for Bone Tissue Engineering. J. Funct. Biomater. 2016, 7, 27.

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