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Mechanotransduction: Tuning Stem Cells Fate

Department of Experimental Medicine and Biochemical Science, Section of Biochemistry and Molecular Biology, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
Materials Engineering Centre, UdR INSTM, NIPLAB, University of Perugia, Strada di Pentima 4, 05100 Terni, Italy
Institute of Polymer Science and Technology, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2011, 2(2), 67-87;
Received: 6 May 2011 / Revised: 7 June 2011 / Accepted: 17 June 2011 / Published: 21 June 2011
(This article belongs to the Special Issue Stem Cells and Biomaterials)
It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological-like fashion, could drive stem cell fate both in vitro and in vivo. The rationale is that stem cells are highly sensitive to forces and that they may convert mechanical stimuli into a chemical response. In this review, we describe novelties on stem cells and biomaterials interactions with more focus on the implication of the mechanical stimulation named mechanotransduction. View Full-Text
Keywords: ESCs; ASCs; iPS; mechanotransduction; regenerative medicine; tissue engineering ESCs; ASCs; iPS; mechanotransduction; regenerative medicine; tissue engineering
MDPI and ACS Style

D’Angelo, F.; Tiribuzi, R.; Armentano, I.; Kenny, J.M.; Martino, S.; Orlacchio, A. Mechanotransduction: Tuning Stem Cells Fate. J. Funct. Biomater. 2011, 2, 67-87.

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