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A Critical Review on Selected External Physical Cues and Modulation of Cell Behavior: Magnetic Nanoparticles, Non-thermal Plasma and Lasers

1
Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic
2
Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2019, 10(1), 2; https://doi.org/10.3390/jfb10010002
Received: 16 November 2018 / Revised: 13 December 2018 / Accepted: 21 December 2018 / Published: 24 December 2018
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Abstract

Physics-based biomedical approaches have proved their importance for the advancement of medical sciences and especially in medical diagnostics and treatments. Thus, the expectations regarding development of novel promising physics-based technologies and tools are very high. This review describes the latest research advances in biomedical applications of external physical cues. We overview three distinct topics: using high-gradient magnetic fields in nanoparticle-mediated cell responses; non-thermal plasma as a novel bactericidal agent; highlights in understanding of cellular mechanisms of laser irradiation. Furthermore, we summarize the progress, challenges and opportunities in those directions. We also discuss some of the fundamental physical principles involved in the application of each cue. Considerable technological success has been achieved in those fields. However, for the successful clinical translation we have to understand the limitations of technologies. Importantly, we identify the misconceptions pervasive in the discussed fields. View Full-Text
Keywords: magnetic nanoparticles; non-thermal plasma; lasers; cytotoxicity; cell signaling magnetic nanoparticles; non-thermal plasma; lasers; cytotoxicity; cell signaling
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Smolková, B.; Uzhytchak, M.; Lynnyk, A.; Kubinová, Š.; Dejneka, A.; Lunov, O. A Critical Review on Selected External Physical Cues and Modulation of Cell Behavior: Magnetic Nanoparticles, Non-thermal Plasma and Lasers. J. Funct. Biomater. 2019, 10, 2.

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