## 1. Introduction: The Question of Substance

“There is some elementary but not widely understood theory that glues the whole thing together.”S. B. Cooper [1]

“This suggests that in general there is nothing ‘physical’ about the information content per se. It depends entirely on relations, and the relations can change. In other words, besides material properties, we have to speak about informational properties now, or, going even beyond that, we may realize there exists only the latter, as perhaps the material properties themselves can be conceived as instances of some permanent relation or mode of interaction. In short, instead of single and well-defined causes and actions, we are left with an intricate web of modalities that jointly evoke or define a dominant trait or observed action.” [9].

## 2. Informational Nature of Matter

## 3. Computational Nature of Process

## 4. Gluing it all Together: Information/Computation—Matter/Energy—Structure/Process in an Organic Whole

## 5. The Nature of the Relationships

- Information 1 (Shannon) (data, pattern, signal) (data communication) [what it exhibits—syntax]
- Information 2 (Shannon + Boltzmann) (intentionality, aboutness, reference, representation, relation to object or referent) [what it conveys—semantics]
- Information 3 ((Shannon + Boltzmann) + Darwin) (function, interpretation, use, pragmatic consequence) [what it’s for—pragmatics]

## 6. Open Systems and Non-Equilibrium Processes. Complex Dynamical Systems Theory beyond the Mechanicism

## 7. Fully Fledged Causation—Bottom-up, Top-down and Back. Deacon’s “Absentials”

## 8. Conclusions

## Acknowledgements

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