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Nanotechnology as an Alternative to Reduce the Spread of COVID-19

Department of Biology and The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio. One UTSA Circle, San Antonio, TX 78249, USA
Author to whom correspondence should be addressed.
Challenges 2020, 11(2), 15;
Received: 23 June 2020 / Revised: 22 July 2020 / Accepted: 24 July 2020 / Published: 27 July 2020
(This article belongs to the Section Trends)


The current emerging COVID-19 pandemic has caused a global impact on every major aspect of our societies. It is known that SARS-Cov-2 can endure harsh environmental conditions for up to 72 h, which may contribute to its rapid spread. Therefore, effective containment strategies, such as sanitizing, are critical. Nanotechnology can represent an alternative to reduce the COVID-19 spread, particularly in critical areas, such as healthcare facilities and public places. Nanotechnology-based products are effective at inhibiting different pathogens, including viruses, regardless of their drug-resistant profile, biological structure, or physiology. Although there are several approved nanotechnology-based antiviral products, this work aims to highlight the use of nanomaterials as sanitizers for the prevention of the spread of mainly SARS-Cov-2. It has been widely demonstrated that nanomaterials are an alternative for sanitizing surfaces to inactivate the virus. Also, antimicrobial nanomaterials can reduce the risk of secondary microbial infections on COVID-19 patients, as they inhibit the bacteria and fungi that can contaminate healthcare-related facilities. Finally, cost-effective, easy-to-synthesize antiviral nanomaterials could reduce the burden of the COVID-19 on challenging environments and in developing countries.
Keywords: COVID-19; nanotechnology; nanomaterials; antiviral; sanitizers; nanomedicine; infectious diseases COVID-19; nanotechnology; nanomaterials; antiviral; sanitizers; nanomedicine; infectious diseases

1. Introduction

Other than a natural disaster of cataclysmic proportions, or an all-out man-made nuclear war, infectious diseases pose the only global threat to human life on Earth. Infectious diseases have plagued humanity and represented the major cause of morbidity and mortality through the millennia, and in the process shaped human evolution. They still constitute the leading cause of premature death in the developing world. However, our modern society has become extremely complacent about the threat posed by infectious diseases, mostly due to the availability and increased access to hygiene and sanitization techniques, vaccines, and antibiotics.
Despite this unjustified level of complacency and the false sense of security, epidemiological experts and sentinel organizations around the world have provided ample warning signs, often ignored, of our global vulnerability against infectious diseases and their broad and borderless impact. Microorganisms do not need a passport and do not understand artificial geopolitical boundaries. This is further aggravated by globalization and climate change. In particular, the newest epidemics caused by a virus such as SARS, MERS, Ebola, and H1N1 since the beginning of the century have raised the awareness of the major threat that viral diseases still pose to humanity as a whole. However, these preoccupations were often short-lived and fast forgotten once the resulting epidemics were seemingly under control, which left us completely unprepared despite our conviction and anticipation that it was only a matter of time for the next epidemic or pandemic to come. Sure enough, we did not have to wait too much longer, and as of early 2020, humanity is confronting a pandemic in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease, abbreviated as COVID-19.

2. The SARS-CoV-2 Virus and the Current COVID-19 Pandemic

The SARS-CoV-2 is a large, enveloped, positive-stranded RNA virus, with a nucleocapsid, with a similar structure to the SARS-CoV-1; and a diameter size range from 80 to 140 nm [1]. This zoonotic coronavirus has become a major cause of emerging respiratory disease and has rapidly spread around the globe, affecting billions of people, and triggering unexpected changes in the healthcare system, global economy, and interactions in societies worldwide.
So far, as of 23th July, there are over 14.6 million confirmed cases with COVID-19 worldwide, with an estimated death toll of over 607,000 people [2]. The costs related to this communicable disease are expected to be in the trillions of dollars globally, but the real cost cannot be estimated [3]. Implementing strategies to reduce its spread requires the participation of the whole society, as well as the development of innovative ways of social, work, and health policies. Several measures have been implemented to control COVID-19, from campaigns aimed at improving personal hygiene practices to community approaches such as social distancing and quarantines. Among the suggested public health activities to address this pandemic are (1) efficient stay-at-home implementation, (2) fast SARS-CoV-2 testing, and (3) efficient health care response. The last point considers protecting the health care professionals by providing tools to prevent nosocomial infections, from making appropriate personal protective equipment (PPE) available to ensuring sanitizing procedures.
Proper sanitizing measures are critical. A recent study revealed that SARS-CoV-2 can be detected on plastic and stainless-steel surfaces up to 72 h, whereas on copper, no viable SARS-CoV-2 was measured after 4 h of application [4]. The inactivation of the virus by copper is not surprising, as it is known that transition metals can inactivate viral particles [5]. Thus, nanotechnology may provide an alternative for sanitizing surfaces, via antimicrobial and antiviral nanomaterials.

3. The State-of-the-Art of Antiviral Nanomaterials: From Research to the Clinic

3.1. Nanomaterial Definition

There are different definitions of the nanomaterial concept. In general, nanomaterials can be described as single-structures—free or in a composite—with a size within the nanometric range, usually less than 100 nm in at least one of their three dimensions. Within the nanometric range—the nanoscale—the physicochemical properties of materials display significant changes that contrast their counterparts at larger scales, as the quantum effects determine their new properties [6]. There is an increasing interest in nanomaterials, precisely due to their novel or improved physicochemical properties such as endurance, chemical reactivity, biocompatibility, conductivity, or reduced toxicity [7]. The chemical composition of nanomaterials can be organic or inorganic, and they can be found as single structures, composites, embedded in a matrix, etc. Nowadays, nanomaterials are found in a wide range of existing products, such as in electronics, health and fitness, paints and other surface coatings, food, and clothing, among many others [8,9,10]. Moreover, medicine is among the areas with a growing interest in the use of nanotechnology.

3.2. Use in Nanomedicine

Nanomaterials are widely used in different healthcare-related applications, such as sanitizers, diagnosis, imaging tools, wound dressing, wearable devices, anticancer therapies, pharmaceuticals, drug delivery, vaccines, diagnosis techniques, and implants, among others [11,12,13]. Nanomaterials have been researched for developing antiviral and antimicrobial drugs, as they display properties for combatting multiple pathogenic microorganisms [14,15,16,17,18,19,20]. The global consumption for healthcare-related nanotechnology is expected to be over 50 tons, just for silver nanoparticles, in 2020 [21].
Multiple nanomaterials can display antiviral activity. The chemical composition of these nanomaterials can be either organic or inorganic (metal-based); their typical shape is spheroid or polyandric (aspect ratio close to 1) with a usual size range from 1 to 50 nm, and their active formulation is often as free particles in suspension. Antiviral nanomaterials are typically smaller than most viral particles, such as the SARS-Cov-2 viral particle, which has an average size of 120 nm [1] (Figure 1). Therefore, nanomaterials can interact with the whole viral particle or with the surface proteins and other structural components, leading to the inactivation of viruses. The characteristics of antiviral nanomaterials, their potential mechanisms of action, the ongoing preclinical/clinical research, and the currently approved products for consumer use are discussed below.

3.3. Preclinical Studies, In Vitro and In Vivo

The antiviral activity of nanomaterials against multiple viral families has been studied in a wide diversity of reports (Table 1). Studies in vitro show that silver nanoparticles (AgNPs) inactivate different types of viruses, such as HIV-1 [22], monkeypox virus [23], hepatitis B [24], Tacaribe virus [25], and the Rift Valley fever virus [26]. Also, AgNPs display activity against influenza viruses like H3N2 [27] and H1N1 [28]. Current literature suggests that nanomaterials may also effectively inactivate the SARS-Cov-2 virus particles, as nanomaterials have been used for inhibiting other viruses from the Coronaviridae family [29]. Other nanomaterials also display antiviral activity against viruses that cause respiratory syndromes. Titanium oxide nanoparticles inhibit the H9N2 [30], carbon fullerene lipidosomes inactivate H1N1 [31], and a peptide–nanoparticle complex is capable of inactivating the influenza A virus [32]. Regarding other viruses, ivermectin-nanoparticles complexes can inactivate the Zika virus [33]. Therefore, nanomaterials can inactivate a wide variety of viruses, regardless of the viral structure and strain [34].
Moreover, several studies report the effectivity of nanomaterials for reducing viral replication, in vivo against viruses from multiple families (Table 2). In murine models, different nanomaterials are effective to inhibit the respiratory syncytial virus [35]; HIV [36], influenza virus [37], herpes simplex virus, human papillomavirus, dengue and lentivirus [38]. Additionally, antiviral nanomaterials display antiviral activity in other in vivo models; such as the canine distemper virus in dogs [39], the Newcastle disease virus in chicken [40], and the white spot syndrome virus in shrimp [41], among others.

3.4. Mechanisms of Action of Antiviral Nanomaterials

Preclinical trials have shown how virus-nanoparticle interactions lead to direct or indirect antiviral activity. Nanomaterials with indirect activity do not inhibit the viruses by themselves; instead, they improve the activity of the antiviral treatments, and are used for transport [44], stability [45], and enhanced bioavailability [46], among others. Moreover, nanomaterials can also induce an immune response for generating short or long-term immunity [47]. In contrast, nanomaterials with direct activity act as the active compound, because they inactivate the viruses by themselves, usually by altering the viral structure or its genetic material.
Back in 2005, Lara et al., showed that AgNPs interact with the receptors from HIV, inhibiting its infectivity [48]. They suggested that AgNPs bind to the gp120 glycoprotein knobs, preventing the virus from binding to cells, as observed in their in vivo results. Also, Morris et al., suggested recently that AgNPs may be attaching to the surface glycoproteins of the virus [35]; which prevents the fusion process by reducing its ability to attach to the cells. Additionally, Cagno et al., showed that gold and iron oxide nanoparticles—coated with organic ligands—disrupt the ultrastructure of multiple viruses [38], breaking the viral particle, leading to virucidal inhibition of enveloped and naked viruses. Moreover, Kim et al., demonstrated that nanomaterials can silence viral genes, as they observed that in vivo administration of anti-CCR5 siRNA/LFA-1 I-tsNPs exclusively silenced genes in leukocyte for around 10 days, preventing the HIV infection [42]. In a recent review, Cojocaru et al., described the potential mechanisms that allow nanomaterials to inactivate both DNA and RNA viruses [49]. Among the main mechanisms are the viral DNA/RNA synthesis inhibition; viral protein synthesis inhibition; and inhibitors of the entry, fusion, or integration of viruses into the cell. The general mechanisms that nanomaterials display against viruses are exemplified in Figure 2.
Moreover, nanomaterials display other properties of clinical interest, such as enhanced chemical reactivity and biocompatibility, controlled drug release, and customizable target specificity [50,51], and may display reduced toxicity when compared to the non-nanostructured materials.

3.5. Clinical Studies and Products in the Market

Nowadays, multiple antiviral nanomedicines are still under clinical research, whereas others have been approved and are currently commercially available for use. Some recent reviews show the current stage of development of antiviral nanomedicines, from ongoing preclinical and clinical trials to those that are currently approved. Lembo et al., review how nanotechnology-based formulations improve the activity of antiviral drugs, describing the advantages provided by different nanomaterials [52]; whereas Sato et al., provide an insight of the status of several therapeutics anti-HBV undergoing clinical trials in phases 1 and 2 [47]; finally, Singh et al., present an overview of the research of nanomaterials, from preclinical research to clinical assays and commercialization, for the treatment of viral infections [53]. Some examples of FDA-approved, nanotechnology-based products are Inflexal V©, a virosomal anti-influenza vaccine, [44], and Pegasys©, a pegylated IFN alpha 2a anti-Hepatitis (HBV and HVC) [54].

4. Current Nanotechnology Applications that Can Be Used to Combat COVID-19

As mentioned earlier, nanomaterials are currently used in multiple commercially available products, including cosmetics and healthcare. A detailed, updated list of products can be consulted at the Nanowerk databases [9]. The wide range of physical and chemical properties of nanomaterials provides numerous advantages to combat the SARS-Cov-2; from reducing its spread to future treatments. When antiviral nanomaterials are fixed in support, their stability and reactivity are increased, as well as the surface area of the support. Usually, nanomaterials are adsorbed by textiles [55] and polymers [56] for diverse applications, such as personal protective equipment (PPE), medical textiles, packaging, and filters. Nanomaterials in suspensions can be used for sanitizing, coatings, and therapeutic applications. Finally, multiple nanomaterials can be used for nanocarriers, diagnosis, and detection. Some of the current applications that can be used to prevent and treat the COVID-19 are described below and summarized in Figure 3.

4.1. Personal Protective Equipment (PPE)

The application of nanomaterials-embedded textiles has been intensely researched, as they improve the physicochemical properties of textiles, such as fire-retardant, self-cleaning, antimicrobial, and UV-protection, among others [57,58]. Fibers embedded with metallic nanoparticles, such as copper and silver nanoparticles, display antimicrobial and antiviral properties [11,59]. Mao recently reviewed the use of nanotechnology for protective clothing—including PPE such as lab coats, aprons, and facemasks—as nanomaterials provide novel traits to the fabrics [60]. Nowadays, the use of nanoparticles in textiles has been increasing rapidly, with a current global consumption of around 35 tons just for silver nanoparticles [21]. Moreover, wearable smart textiles and electronics for sensing have been explored, particularly for health-related applications, as described by Libertino et al., as the early detection of pathogens is of particular interest [61]. Jayathilaka et al., suggest that wearables and textiles may be also used for drug delivery [62].

4.2. Surface Coatings

Nanomaterials-based coatings are currently used for several applications, and different products are now available, particularly from metallic elements such as silver, bismuth, copper, or titanium [11,58,63,64]. Also, nanostructured surfaces can physically reduce the attachment of pathogens [65] and even disrupt the structure of the pathogens due to the nanoscale topography organization [66]. Nanomaterials can be embedded in paints or coatings for medical instrumentation, walls, and other highly-touched surfaces, such as doorknobs, handrails, etc. for reducing the presence and viability of viruses and other pathogens. A recent review by Rai et al., describes multiple nanocoatings and their potential use in public places for reducing the presence of pathogens [67].

4.3. Disinfectants and Sanitizing Procedures

Disinfectants with silver salts are currently used [68], as silver is deemed safe for sanitizing purposes [69]. In hospitals and other healthcare-related facilities, sanitizing with nanotechnology-based products could decrease the viral presence on highly-touched surfaces and maintain them virus-free for longer, including the SARS-Cov-2 virus. Metallic nanoparticles may be a viable option, as the viability of the SARS-Cov-2 virus is reduced on a metallic (copper) surface [4].

4.4. Other Current and Potential Applications

Among other uses, nanomaterials can be used to improve the function of air filters in healthcare facilities or in other places that use recirculated air. Nanotechnology-improved devices can reduce the spread of viral particles, such as air filters [70,71,72] and for the removal of pathogens and viruses from water [73]. Also, the use of nanotechnology for producing wound dressings has been thoroughly explored [51,74,75], due to their ability to protect against infections and increase the healing speed rate. Future applications may include the development of improved detection kits, as it has been one of the major needs for the current strategies to contain and follow the virus spread. In a recent review, Hameed et al., describe the role of nanotechnology for emerging detection against pathogens [76]. Besides detection, there have been recent advances for nanotechnology-based smart packaging to prevent pathogens [77]. Although the reviews from Hameed et al., and Zhong et al., focus on food-related applications, these can be used in the clinical sector.

5. A Silent Risk: The Microbial Secondary Infections

The current COVID-19 pandemic has raised several health concerns beyond the disease itself, such as secondary infections, which has been an underestimated risk. Secondary infections may appear during or after treatment of the COVID-19, due to the burden on health caused by the virus. Patients infected with the novel strain of coronavirus frequently show microbial dysbiosis and a decrease of probiotic bacteria [78]. Also, it is not uncommon for patients with COVID-19 to suffer from complications of acute organ injury and secondary infection [79], which may be of microbial origin. Recently, Rawson et al., reviewed the current literature regarding microbial co-infections in patients with different coronaviruses; although the co-infection rate is low (8%), they still pose a threat for COVID-19 patients [80].
A major risk associated with microbial infections is drug-resistance, which leads to failures in the treatments of the diseases. Currently, several health institutions worldwide point out that multidrug-resistant pathogens represent an urgent threat, as they cause thousands of deaths and their cost is incalculable. The CDC, in its latest Antibiotic Resistance Threats in the United States, lists current clinically microbial pathogens and describes the challenges associated with drug resistance [81]. Moreover, an additional threat is the formation of microbial biofilms (layers of microbial cells protected by an extracellular matrix), as they allow the microbial pathogens to survive sanitizing procedures harsh conditions. Biofilms allow microbial pathogens to have a constant presence in health-related facilities. Among the alternatives to combat pathogens, antimicrobial nanomaterials (nanoantibiotics) have been rising as a viable option.
Nanoantibiotics display a broad range antimicrobial activity against bacteria [82,83], protozoa [84,85], and fungi [86,87,88,89]. Metallic nanoparticles have been extensively studied, as metals have intrinsic antimicrobial properties [90] and they display antimicrobial activity regardless of the drug-susceptibly profile of microorganisms [15,86]. Additionally, nanomaterials may enhance the potency of current antimicrobial drugs; Vazquez-Munoz et al. recently described a potential mode of action between AgNPs and antibiotics that lead to synergistic effects [91]. Moreover, nanomaterials can reduce the microbial biofilms leading to a reduced risk of secondary microbial infections [87,88,92]. In Table 3 are listed examples of antimicrobial nanomaterials, with their properties and applications.
An additional advantage is that there are a plethora of methods for synthesizing nanomaterials [100]; some methods can be easily reproduced in non-specialized facilities under unfavorable environments [101], therefore they could be produced for sanitizing in rural areas, mobile medical units, or in medical posts for the military on the field.

6. Perspectives

What should be expected in the near future? Although more research is needed, antiviral nanomaterials represent an alternative to reduce the spread of COVID-19, as they have been effective against other viruses. Based on the current knowledge, nanomaterials may be used in the present or the short-term for preventing the spread of the SARS-Cov-2 virus using antiviral sanitizers, nanotechnology-upgraded materials for PPE and medical instrumentation, and nanotechnology-enhanced fabrics for facemasks for general use. Particularly, nanotechnology-based sanitizers also display potent and broad antiviral and antimicrobial activity, therefore they can improve safety in healthcare-related facilities and public spaces, particularly in developing countries.
Regarding upcoming applications, nanotechnology can be used for detection kits, vaccines, and treatments. Currently, the therapeutic use of antiviral nanotechnology-based drugs has proven to be effective and it will be expanded in the future as more research becomes available. Also, nanomaterials display a broad range of activity and they may enhance the antimicrobial potency of some drugs, therefore they can be used for preventing or treating secondary infections, particularly those with multidrug-resistant profiles.
Finally, protocols that favor facile, rapid, cost-effective syntheses of antimicrobial and antiviral nanomaterials produce potent nanomaterials that could reduce the spread of viruses and microorganisms. Affordable nanotechnology may benefit anti-COVID-19 sanitizing procedures in developing countries, where access to advanced materials is limited. Also, easy-to-synthesize nanomaterials may be used under non-favorable conditions, such as medical mobile-units, rural health care facilities, and highly transited public spaces.

Author Contributions

Both authors equally contributed to the conceptualization, writing-original draft preparation, and writing-review & editing. All authors have read and agreed to the published version of the manuscript.


R.V.-M. acknowledges support from a postdoctoral fellowship from the Mexican Council of Science and Technology (CONACYT). J.L.L.-R. acknowledges support from the Margaret Batts Tobin Foundation. The authors would like to thank the graphic designer Salma Carballo for designing the images.

Conflicts of Interest

The authors declare no conflict of interest.


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Figure 1. Size comparison between the average sizes of the SARS-Cov-2 coronavirus and a single silver nanoparticle (AgNPs). Both structures are at a proportional size.
Figure 1. Size comparison between the average sizes of the SARS-Cov-2 coronavirus and a single silver nanoparticle (AgNPs). Both structures are at a proportional size.
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Figure 2. Proposed antiviral mechanisms that nanoparticles use to deactivate viruses.
Figure 2. Proposed antiviral mechanisms that nanoparticles use to deactivate viruses.
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Figure 3. Representative uses of nanotechnology to combat viruses and other pathogens.
Figure 3. Representative uses of nanotechnology to combat viruses and other pathogens.
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Table 1. A non-exhaustive list of examples of antiviral nanomaterials that inactivate different types of viruses, in preclinical assays in vitro.
Table 1. A non-exhaustive list of examples of antiviral nanomaterials that inactivate different types of viruses, in preclinical assays in vitro.
Antiviral NanomaterialVirusRefs
Type/CompositionShapeSize 1 (nm)Coating
AgNPsSpheroid2.08 BSAHIV-1[22]
Spheroid25, 55, 80chitosanMonkeypox[23]
N/A 10, 50N/A Hepatitis[24]
Spheroid 10, 25Uncoated & PolysaccharideTacaribe[25]
Spheroid 35 PVPRVFV[26]
Spheroid 9.5 OrganicH3N2[27]
Spheroid 3.5, 12.9ChitosanH1N1[28]
Spheroid 5–25 Graphene oxideCoronavirus[29]
Carbon fullerene 2N/AN/AN/AH1N1[31]
Peptide–NPs 3Dendritic2.4 & 29.8N/AInfluenza A[32]
Ivermectin-NPs 3Spheroid 60–140IVMZika[33]
1 Average size. For the metallic nanoparticles, the size corresponds to their metallic core. 2 Lipidosome complex. 3 Hybrid complexes.
Table 2. A non-exhaustive list of examples of antiviral nanomaterials under preclinical assays in vivo.
Table 2. A non-exhaustive list of examples of antiviral nanomaterials under preclinical assays in vivo.
In Vivo AssayAntiviral NanomaterialRefs
ModelVirus 1Type 2Traits
MurineRSVAgNPs10 nm spheres, PVP coated[35]
HIVPLGA NPs 66 nm spheroids, ƺ-pot = −10.96 mV[36]
I-tsNPs 100 nm liposome spheroids, ƺ-pot = −9.2 mV[42]
Maraviroc-SDNMultiple NPs: Size 650–850 nm.[43]
InfluenzaNano-Emulsion223–228 nm[37]
HSV, RSV, HPV, DV, LVHSPG-NPs<7 nm, gold core, MES- or MUS-coated [38]
DogsCDVAgNPs35 nm, spheroids, PVP-coated[39]
ChickenNDV PR-NPs<80 nm spherical[40]
Shrimp WSSV chitosan NPs160 nm[41]
1 RSV = respiratory syncytial Virus, HIV = human immunodeficiency virus, HSV = herpes simplex virus, HPV = human papillomavirus, DV = dengue, LV= lentivirus, CDV = canine distemper virus, NDV = Newcastle disease virus; WSSV= white spot syndrome virus. 2 PLGA (poly[lactic-co-glycolic acid]) NPs; HSPG (heparan sulfate proteoglycans)-mimicking NPs; I-tsNPs= anti-CCR5 siRNA/LFA-1 I-tsNPs; PR-NPs= Polyrhodanine nanoparticles.
Table 3. Examples of types of nanoantibiotics with current and expected antimicrobial applications.
Table 3. Examples of types of nanoantibiotics with current and expected antimicrobial applications.
NanomaterialsCommon Antimicrobial ApplicationsRefs
TypeRelevant Traits *PathogensUses **
SilverHigh activity
Synergistic effects
Functional coating
Bacteria, Fungi, ProtistsTextiles, Coating, Cosmetics, Sanitizers, Treatments[14,93]
GoldBinding with antibiotics
Low toxicity
Functional coating
BacteriaTreatments, Detection, Textiles, Wearables[94]
High stability
Bacteria, Fungi Coating, Dentistry[95]
CopperStabilityBacteria, Fungi Coating[96]
Lipid-based Non-toxic
Bacteria, Fungi, ProtistsDrug delivery, Cosmetics[54,97,98]
Support for metals
Bacteria, Fungi Drug delivery, Textiles[97,99]
* Distinctive traits are mentioned. These nanomaterials usually display an aspect ratio close to 1 (polyhedral or spheroids) with a size range within 5–50 nm. They can be coated to add new properties. ** Current and intended uses.
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