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Effect of a Combination of Myo-Inositol, Alpha-Lipoic Acid, and Folic Acid on Oocyte Morphology and Embryo Morphokinetics in non-PCOS Overweight/Obese Patients Undergoing IVF: A Pilot, Prospective, Randomized Study

Gynecology and Obstetrics 1, Physiopathology of Reproduction and IVF Unit, S. Anna Hospital, Department of Surgical Sciences, University of Torino, Via Ventimiglia 3, 10126 Torino, Italy
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J. Clin. Med. 2020, 9(9), 2949; https://doi.org/10.3390/jcm9092949
Received: 31 July 2020 / Revised: 28 August 2020 / Accepted: 7 September 2020 / Published: 12 September 2020
(This article belongs to the Section Obstetrics & Gynecology)
Herein we aimed at assessing whether Myo-Inositol (MI), Alpha–Lipoic acid (ALA), and Folic acid (FA) could improve oocyte quality and embryo development in non-PCOS overweight/obese women undergoing IVF. Three hundred and twenty-four mature oocytes were obtained from non-PCOS overweight/obese patients, randomized to receive either MI, ALA, and FA (MI + ALA + FA group, n = 155 oocytes) or FA alone (FA-only group, n = 169 oocytes). Oocytes were examined using Polarized Light Microscopy to assess morphological features of zona pellucida (ZP) and meiotic spindle (MS). One hundred and seventy-six embryos (n = 84 in the MI + ALA + FA group, n = 92 in the FA-only group) were assessed by conventional morphology on days 2 and 5, as well as using the Time-Lapse System morphokinetic analysis. A significantly higher ZP retardance, area, and thickness (p < 0.05), and a shorter MS axis (p < 0.05) were observed in the MI + ALA + FA group, suggesting a positive effect on oocyte quality. Conventional morphology evaluation on day 2 showed a higher mean embryo score in the MI + ALA + FA group, whereas embryo morphokinetic was comparable in the two groups. Overall, our data show a possible beneficial effect of the combination of MI, ALA, and FA on oocyte and embryo morphology, encouraging testing of this combination in adequately powered randomized trials to assess their impact of clinical IVF results. View Full-Text
Keywords: Myo-Inositol; oocyte quality; polarized light microscopy; embryo morphokinetics; overweight patients; obesity; IVF Myo-Inositol; oocyte quality; polarized light microscopy; embryo morphokinetics; overweight patients; obesity; IVF
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MDPI and ACS Style

Canosa, S.; Paschero, C.; Carosso, A.; Leoncini, S.; Mercaldo, N.; Gennarelli, G.; Benedetto, C.; Revelli, A. Effect of a Combination of Myo-Inositol, Alpha-Lipoic Acid, and Folic Acid on Oocyte Morphology and Embryo Morphokinetics in non-PCOS Overweight/Obese Patients Undergoing IVF: A Pilot, Prospective, Randomized Study. J. Clin. Med. 2020, 9, 2949. https://doi.org/10.3390/jcm9092949

AMA Style

Canosa S, Paschero C, Carosso A, Leoncini S, Mercaldo N, Gennarelli G, Benedetto C, Revelli A. Effect of a Combination of Myo-Inositol, Alpha-Lipoic Acid, and Folic Acid on Oocyte Morphology and Embryo Morphokinetics in non-PCOS Overweight/Obese Patients Undergoing IVF: A Pilot, Prospective, Randomized Study. Journal of Clinical Medicine. 2020; 9(9):2949. https://doi.org/10.3390/jcm9092949

Chicago/Turabian Style

Canosa, Stefano, Carlotta Paschero, Andrea Carosso, Sara Leoncini, Noemi Mercaldo, Gianluca Gennarelli, Chiara Benedetto, and Alberto Revelli. 2020. "Effect of a Combination of Myo-Inositol, Alpha-Lipoic Acid, and Folic Acid on Oocyte Morphology and Embryo Morphokinetics in non-PCOS Overweight/Obese Patients Undergoing IVF: A Pilot, Prospective, Randomized Study" Journal of Clinical Medicine 9, no. 9: 2949. https://doi.org/10.3390/jcm9092949

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