Determinants of Sleep Quality in Inflammatory Bowel Diseases
Abstract
:1. Introduction
2. Experimental Section
2.1. Sample
2.2. Questionnaires
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Parameter | IBD | HC | p | |||
---|---|---|---|---|---|---|
All | Exacerbation | Remission | ||||
n (%) | 133 (70%) | 83 (44%) | 50 (26%) | 57 (30%) | - | |
CD | 68 (51%) | 40 (59%) | 28 (41%) | - | - | |
UC | 65 (49%) | 42 (65%) | 23 (35%) | |||
HBI | 5 (2–8) | 7 (6–9) | 2 (1–3) | - | - | |
PMS | 3 (1–4) | 4 (3–5.75) | 1 (0–1) | |||
n women (%) | 73 (55%) | 40 (48%) | 33 (66%) | 33 (58%) | 1 0.702 3 0.259 | 2 0.422 4 0.752 |
Age | 37.0 (30.0–47.0) | 36.0 (30.0–46.5) | 38.0 (28.5–46.8) | 38.0 (28.0–50.0) | 1 0.899 3 0.882 | 2 0.754 4 0.958 |
BMI (kg/m2) | 23.5 (20.5–26.5) | 23.5 (20.8–27.4) | 23.2 (20.3–26.1) | 24.2 (21.8–25.7) | 1 0.394 3 0.546 | 2 0.736 4 0.341 |
Hypnotic drugs | 18 (13.5%) | 15 (18.1%) | 3 (6.0%) | - | 2 0.066 | |
Steroids treatment | 33 (25%) | 33 (40%) | 0 (0%) | - | - | |
Immuno-modulators | 45 (34%) | 28 (34%) | 17 (34%) | - | - | |
Anti-TNF therpay | 29 (22%) | 29 (35%) | 0 (0%) | - | - |
Parameter | IBD | HC | p | |||
---|---|---|---|---|---|---|
All | Exacerbation | Remission | ||||
PSQI | 5 (4–7) | 5 (4–8) | 5 (3–6.8) | 4 (2–6) | 1<0.001 3<0.001 | 20.008 4 0.067 |
ESS | 6 (4–9) | 6 (4–10.5) | 5 (3–7) | 3 (2–7) | 1<0.001 3<0.001 | 20.009 4 0.105 |
AIS | 5.0 (4.0–8.0) | 6.0 (4.0–9.0) | 5.0 (3.0–7.0) | 3.0 (1.0–6.0) | 1<0.001 3<0.001 | 2 0.021 4 0.019 |
BDI | 7.0 (4.0–11.0) | 8.0 (5.0–12.0) | 5.0 (2.0–9.8) | 2.0 (1.0–4.0) | 1<0.001 3<0.001 | 20.001 40.001 |
VAS | 4.0 (0–5.0) | 5.0 (2.0–5.5) | 2.8 (0–4.9) | 0 (0–3.0) | 1<0.001 3<0.001 | 20.004 40.009 |
LPS | 3.0 (0.0–5.0) | 4.0 (2.0–6.0) | 2.0 (0.0–3.0) | 1.0 (0.0–3.0) | 10.004 3<0.001 | 20.001 4 0.617 |
Sleep latency [min] | 15 (10–30) | 15 (10–35) | 15 (10–30) | 10 (5–15) | 1<0.001 3<0.001 | 2 0.352 4 0.009 |
Hours of sleep | 7.0 (6.0–7.8) | 7.0 (6.0–8.0) | 7.0 (6.0–7.5) | 6.8(6.0–7.3) | 1 0.304 3 0.381 | 2 0.968 4 0.352 |
Hours spent in bed | 8.0 (7.0–8.5) | 8.0 (7.0–8.5) | 8.0 (7.0–8.5) | 7.0 (6.5–8.0) | 1<0.001 3<0.001 | 2 0.824 4 0.002 |
Sleep efficiency (%) | 88.9 (83.2–94.7) | 88.9 (81.8–95.5) | 89.4 (86.2–94.4) | 97.2 (92.9–98.6) | 1<0.001 3<0.001 | 2 0.662 4 <0.001 |
Waking up in the night n (%) | 94 (70.7%) | 66 (79.5%) | 28 (56.0%) | 24 (42.1%) | 1<0.001 3<0.001 | 20.004 4 0.151 |
Factor | PSQI | AIS | ESS | ||||
---|---|---|---|---|---|---|---|
Steroids treatment | Yes | 5.0 (4.0–9.0) | p = 0.210 | 6.0 (4.0–9.0) | p = 0.410 | 6.0 (4.0–8.0) | p = 0.395 |
No | 5.0 (4.0–7.0) | 5.0 (3.0–8.0) | 6.0(3.0–9.0) | ||||
Hypnotic drugs | Yes No | 10.0 (7.0–15.0) 5.0 (4.0–7.0) | p < 0.001 | 7.0 (5.0–10.0) 5.0 (3.0–8.0) | p = 0.040 | 6.0 (3.0–8.0) 6.0 (4.0–9.0) | p = 0.808 |
Abdominal surgery | Yes | 5.0 (4.0–8.0) | p = 0.501 | 7.0 (4.0–9.0) | p = 0.306 | 5.0 (4.0–8.0) | p = 0.424 |
No | 5.0 (4.0–7.0) | 5.0 (3.3–8.0) | 6.0 (4.0–9.8) | ||||
Comorbid chronic diseases * | Yes | 5.0 (4.0–7.0) | p = 0.044 | 6.0 (3.0–8.0) | p = 0.049 | 6.0 (3–8.5) | p = 0.191 |
No | 5.0 (3.0–7.0) | 5.0 (2.5–7.0) | 5.0 (3.0–8.0) | ||||
Fistulas | Yes | 5.0 (3.0–12.0) | p = 0.630 | 6.0 (4.0–8.5) | p = 0.880 | 4.0 (3.0–5.0) | p = 0.057 |
No | 5.0 (4.0–7.0) | 5.0 (4.0–8.0) | 6.0 (4.0–9.0) | ||||
Immuno-modulators | Yes | 5.0 (4.0–7.0) | p = 0.652 | 6.0 (4.0–7.0) | p = 0.841 | 6.0(4.0–11.0) | p = 0.532 |
No | 5.0 (4.0–7.25) | 5.0 (3.0–9.0) | 6.0 (4.0–8.0) | ||||
Anti-TNF therapy | Yes | 5.0 (4.0–8.0) | p = 0.863 | 5.0 (4.0–8.0) | p = 0.575 | 6.0(4.0–9.0) | p = 0.833 |
No | 5.0 (4.0–7.0) | 5.5 (4.0–8.0) | 6.0 (4.0–8.25) |
Correlation | Regression | |||
---|---|---|---|---|
PSQI | ||||
BDI | r = 0.540 | p < 0.001 | b = 0.316 | p < 0.001 |
VAS | r = 0.286 | p = 0.001 | ||
LPS | r = 0.324 | p < 0.001 | ||
R2 = 0.490, b = 3.264, p < 0.001 | ||||
AIS | ||||
BDI | r = 0.533 | p < 0.001 | b = 0.276 | p < 0.001 |
VAS | r = 0.327 | p < 0.001 | b = 0.139 | p = 0.195 |
LPS | r = 0.367 | p < 0.001 | ||
R2 = 0.391, b = 3.318, p < 0.001 | ||||
ESS | ||||
BDI | r = 0.296 | p = 0.001 | b = 0.129 | p = 0.027 |
VAS | r = 0.239 | p = 0.006 | ||
LPS | r = 0.245 | p = 0.004 | b = 0.187 | p = 0.238 |
R2 = 0.092, b = 5.182, p < 0.001 |
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Sochal, M.; Małecka-Panas, E.; Gabryelska, A.; Talar-Wojnarowska, R.; Szmyd, B.; Krzywdzińska, M.; Białasiewicz, P. Determinants of Sleep Quality in Inflammatory Bowel Diseases. J. Clin. Med. 2020, 9, 2921. https://doi.org/10.3390/jcm9092921
Sochal M, Małecka-Panas E, Gabryelska A, Talar-Wojnarowska R, Szmyd B, Krzywdzińska M, Białasiewicz P. Determinants of Sleep Quality in Inflammatory Bowel Diseases. Journal of Clinical Medicine. 2020; 9(9):2921. https://doi.org/10.3390/jcm9092921
Chicago/Turabian StyleSochal, Marcin, Ewa Małecka-Panas, Agata Gabryelska, Renata Talar-Wojnarowska, Bartosz Szmyd, Monika Krzywdzińska, and Piotr Białasiewicz. 2020. "Determinants of Sleep Quality in Inflammatory Bowel Diseases" Journal of Clinical Medicine 9, no. 9: 2921. https://doi.org/10.3390/jcm9092921