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Article

Effects of Topical Prostaglandin Analog on Macular Thickness Following Cataract Surgery with Postoperative Topical Bromfenac Treatment

1
Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon 35015, Korea
2
Department of Ophthalmology, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea
3
Mindeulle Eye Clinic, 9 Samsannam-ro, Boeun 28950, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(9), 2883; https://doi.org/10.3390/jcm9092883
Received: 22 August 2020 / Revised: 4 September 2020 / Accepted: 4 September 2020 / Published: 7 September 2020
(This article belongs to the Special Issue Recommendations for Clinical Management of Glaucoma)
Purpose: To evaluate changes in macular thickness in patients continuing prostaglandin analog (PGA) treatment during the perioperative period involving bromfenac treatment. Methods: Patients with glaucoma who were using a topical PGA were randomly assigned to two groups in this randomized controlled trial: PGA continuing study group and PGA discontinued glaucoma control group. Patients without ocular diseases other than cataract were enrolled into the non-glaucomatous group. After the cataract surgery, the patients used bromfenac twice per day for 4 weeks. Optical coherence tomography was performed in all patients preoperatively and at 1 month postoperatively. Changes in macular thickness were compared among the three groups. Results: There were 32 eyes in the study group, 33 eyes in the glaucoma control group, and 58 eyes in the non-glaucomatous group. We found statistically significant postoperative changes in central macular thickness in all groups (4.30 ± 8.01 μm in the PGA continuing group, 9.20 ± 13.88 μm in the PGA discontinued group, and 7.06 ± 7.02 μm in the non-glaucomatous group, all p < 0.008), but no significant difference among the three groups (p = 0.161). Cystoid macular edema occurred in only one patient in the non-glaucomatous group (p = 0.568). Conclusions: Continuous use of PGAs during the perioperative period was not significantly associated with increased macular thickness after uncomplicated cataract surgery. In the absence of other risk factors (e.g., capsular rupture, uveitis, or diabetic retinopathy), discontinuing PGAs for the prevention of macular edema after cataract surgery with postoperative bromfenac treatment is unnecessary in patients with glaucoma. View Full-Text
Keywords: bromfenac; cystoid macular edema; prostaglandin analog; phacoemulsification; glaucoma bromfenac; cystoid macular edema; prostaglandin analog; phacoemulsification; glaucoma
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MDPI and ACS Style

Park, K.S.; Kim, K.N.; Kim, K.M.; Lee, H.M.; Lee, S.B.; Lee, N.H.; Kim, C.-S. Effects of Topical Prostaglandin Analog on Macular Thickness Following Cataract Surgery with Postoperative Topical Bromfenac Treatment. J. Clin. Med. 2020, 9, 2883. https://doi.org/10.3390/jcm9092883

AMA Style

Park KS, Kim KN, Kim KM, Lee HM, Lee SB, Lee NH, Kim C-S. Effects of Topical Prostaglandin Analog on Macular Thickness Following Cataract Surgery with Postoperative Topical Bromfenac Treatment. Journal of Clinical Medicine. 2020; 9(9):2883. https://doi.org/10.3390/jcm9092883

Chicago/Turabian Style

Park, Kee S., Kyoung N. Kim, Kyeung M. Kim, Han M. Lee, Sung B. Lee, Nam H. Lee, and Chang-Sik Kim. 2020. "Effects of Topical Prostaglandin Analog on Macular Thickness Following Cataract Surgery with Postoperative Topical Bromfenac Treatment" Journal of Clinical Medicine 9, no. 9: 2883. https://doi.org/10.3390/jcm9092883

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