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Open AccessReview

Frontline Management of Epithelial Ovarian Cancer—Combining Clinical Expertise with Community Practice Collaboration and Cutting-Edge Research

1
Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA
2
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
3
Department of Surgical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA
4
Department of Population Sciences, City of Hope National Medical Center, Duarte, CA 91010, USA
5
Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(9), 2830; https://doi.org/10.3390/jcm9092830
Received: 21 July 2020 / Revised: 27 August 2020 / Accepted: 28 August 2020 / Published: 1 September 2020
Epithelial ovarian cancer (EOC) is the most common histology of ovarian cancer defined as epithelial cancer derived from the ovaries, fallopian tubes, or primary peritoneum. It is the fifth most common cause of cancer-related death in women in the United States. Because of a lack of effective screening and non-specific symptoms, EOC is typically diagnosed at an advanced stage (FIGO stage III or IV) and approximately one third of patients have malignant ascites at initial presentation. The treatment of ovarian cancer consists of a combination of cytoreductive surgery and systemic chemotherapy. Despite the advances with new cytotoxic and targeted therapies, the five-year survival rate for all-stage EOC in the United States is 48.6%. Delivery of up-to-date guideline care and multidisciplinary team efforts are important drivers of overall survival. In this paper, we review our frontline management of EOC that relies on a multi-disciplinary approach drawing on clinical expertise and collaboration combined with community practice and cutting edge clinical and translational research. By optimizing partnerships through team medicine and clinical research, we combine our cancer center clinical expertise, community practice partnership, and clinical and translational research to understand the biology of this deadly disease, advance therapy and connect our patients with the optimal treatment that offers the best possible outcomes. View Full-Text
Keywords: epithelial ovarian cancer; frontline treatment; surgical debulking; adjuvant chemotherapy; maintenance therapy; PARP inhibitor; genetics counseling; clinical research; team medicine epithelial ovarian cancer; frontline treatment; surgical debulking; adjuvant chemotherapy; maintenance therapy; PARP inhibitor; genetics counseling; clinical research; team medicine
MDPI and ACS Style

Wang, E.W.; Wei, C.H.; Liu, S.; Lee, S.J.-J.; Shehayeb, S.; Glaser, S.; Li, R.; Saadat, S.; Shen, J.; Dellinger, T.; Han, E.S.; Stewart, D.; Wilczynski, S.; Cristea, M.; Rodriguez-Rodriguez, L. Frontline Management of Epithelial Ovarian Cancer—Combining Clinical Expertise with Community Practice Collaboration and Cutting-Edge Research. J. Clin. Med. 2020, 9, 2830. https://doi.org/10.3390/jcm9092830

AMA Style

Wang EW, Wei CH, Liu S, Lee SJ-J, Shehayeb S, Glaser S, Li R, Saadat S, Shen J, Dellinger T, Han ES, Stewart D, Wilczynski S, Cristea M, Rodriguez-Rodriguez L. Frontline Management of Epithelial Ovarian Cancer—Combining Clinical Expertise with Community Practice Collaboration and Cutting-Edge Research. Journal of Clinical Medicine. 2020; 9(9):2830. https://doi.org/10.3390/jcm9092830

Chicago/Turabian Style

Wang, Edward W.; Wei, Christina H.; Liu, Sariah; Lee, Stephen J.-J.; Shehayeb, Susan; Glaser, Scott; Li, Richard; Saadat, Siamak; Shen, James; Dellinger, Thanh; Han, Ernest S.; Stewart, Daphne; Wilczynski, Sharon; Cristea, Mihaela; Rodriguez-Rodriguez, Lorna. 2020. "Frontline Management of Epithelial Ovarian Cancer—Combining Clinical Expertise with Community Practice Collaboration and Cutting-Edge Research" J. Clin. Med. 9, no. 9: 2830. https://doi.org/10.3390/jcm9092830

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