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Review

Dexmedetomidine: What’s New for Pediatrics? A Narrative Review

1
Department of Anesthesia, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
2
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy
3
Department of Medicine, Surgery, and Health Sciences, University of Trieste, 34137 Trieste, Italy
4
Department of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston Children’s Hospital, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(9), 2724; https://doi.org/10.3390/jcm9092724
Received: 1 July 2020 / Revised: 17 July 2020 / Accepted: 28 July 2020 / Published: 24 August 2020
(This article belongs to the Section Anesthesiology)
Over the past few years, despite the lack of approved pediatric labelling, dexmedetomidine’s (DEX) use has become more prevalent in pediatric clinical practice as well as in research trials. Its respiratory-sparing effects and bioavailability by various routes are only some of the valued features of DEX. In recent years the potential organ-protective effects of DEX, with the possibility for preserving neurocognitive function, has put it in the forefront of clinical and bench research. This comprehensive review focused on the pediatric literature but presents relevant, supporting adult and animal studies in order to detail the recent growing body of literature around the pharmacology, end-organ effects, organ-protective effects, alternative routes of administration, synergetic effects, and clinical applications, with considerations for the future. View Full-Text
Keywords: pediatric; anesthesia; sedation; pharmacology; neurotoxicity; neuroprotection; side effects pediatric; anesthesia; sedation; pharmacology; neurotoxicity; neuroprotection; side effects
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MDPI and ACS Style

Mahmoud, M.; Barbi, E.; Mason, K.P. Dexmedetomidine: What’s New for Pediatrics? A Narrative Review. J. Clin. Med. 2020, 9, 2724. https://doi.org/10.3390/jcm9092724

AMA Style

Mahmoud M, Barbi E, Mason KP. Dexmedetomidine: What’s New for Pediatrics? A Narrative Review. Journal of Clinical Medicine. 2020; 9(9):2724. https://doi.org/10.3390/jcm9092724

Chicago/Turabian Style

Mahmoud, Mohamed, Egidio Barbi, and Keira P. Mason 2020. "Dexmedetomidine: What’s New for Pediatrics? A Narrative Review" Journal of Clinical Medicine 9, no. 9: 2724. https://doi.org/10.3390/jcm9092724

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