Relationship between Tube Parameters and Corneal Endothelial Cell Damage after Ahmed Glaucoma Valve Implantation: A Comparative Study
Abstract
:1. Introduction
2. Methods
2.1. Patients
2.2. Corneal Specular Microscopy
2.3. Anterior Segment Optical Coherence Tomography
2.4. Statistical Analyses
3. Results
Demographics
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Characteristics | Patients with ECD Damage (Group 1, n = 30) | Patients without ECD Damage (Group 2, n = 63) | p-Value |
---|---|---|---|
Age (years, mean ± SD) | 64.60 ± 11.63 | 60.41 ± 13.58 | 0.150 |
Sex (M/F) | 24/6 | 42/21 | 0.227 |
Laterality (R/L) | 15/15 | 31/32 | 1.000 |
Systemic disease, n (%) | |||
DM | 10 (33.33) | 26 (41.27) | 0.503 |
HTN | 14 (46.67) | 30 (47.62) | 1.000 |
CVA | 1 (3.33) | 1 (1.59) | 0.543 |
Axial length (mm) | 24.58 ± 2.06 | 24.37 ± 2.12 | 0.641 |
Anterior chamber depth (mm) | 4.06 ± 0.96 | 3.81 ± 0.86 | 0.238 |
Baseline ECD (cells/mm2) | |||
Average * | 2194.03 ± 572.08 | 2324.19 ± 510.16 | 0.272 |
Center | 2182.03 ± 569.97 | 2320.33 ± 500.55 | 0.237 |
Superior-temporal | 2184.60 ± 574.20 | 2311.90 ± 532.75 | 0.296 |
Diagnosis, n (%) | 0.275 † | ||
Neovascular glaucoma | 10 (33.33) | 30 (47.62) | |
Primary open-angle glaucoma | 9 (30.00) | 11 (17.46) | |
Uveitic glaucoma | 5 (16.67) | 11 (17.46) | |
Chronic angle-closure glaucoma | 3 (10.00) | 1 (1.59) | |
Pseudoexfoliation glaucoma | 1 (3.33) | 2 (3.17) | |
Steroid induced glaucoma | 1 (3.33) | 1 (1.59) | |
Other secondary glaucoma | 1 (3.33) | 7 (11.11) | |
Preoperative IOP (mmHg) | 36.63 ± 9.76 | 38.97 ± 11.76 | 0.234 |
Postoperative mean IOP (mmHg) | 18.27 ± 4.25 | 19.13 ± 5.27 | 0.489 |
Final IOP (mmHg) | 16.35 ± 3.45 | 15.71 ± 4.34 | 0.561 |
Follow-up period (months) | 29.30 ± 14.67 | 27.75 ± 11.63 | 0.582 |
Postoperative topical CAI | 15 (50.00) | 35 (53.85) | 0.661 † |
Tube Parameters | Patients with ECD Damage (Group 1, n = 30) | Patients without ECD Damage (Group 2, n = 63) | p-Value |
---|---|---|---|
Tube length (mm) | 2.21 ± 0.70 | 2.21 ± 0.69 | 0.989 |
Tube-cornea distance (mm) | 0.98 ± 0.38 | 1.26 ± 0.39 | 0.002 |
Tube-cornea angle (degree) | 28.67 ± 7.79 | 36.35 ± 5.35 | <0.001 |
Corneal Area | Patients with ECD Damage (Group 1, n = 30) | p-Value | Patients without ECD Damage (Group 2, n = 63) | p-Value | p-Value * |
---|---|---|---|---|---|
Average † | −18.82 ± 22.97 (412.91 ± 503.96) | <0.001 | 2.14 ± 2.93 (49.74 ± 68.10) | 0.342 | <0.001 |
Center | −17.82 ± 25.01 (388.84 ± 545.73) | <0.001 | 1.95 ± 3.06 (45.25 ± 71.00) | 0.612 | <0.001 |
Superior temporal (ST) | −30.38 ± 26.18 (663.68 ± 571.93) | <0.001 | 2.56 ± 4.21 (59.18 ± 97.33) | 0.440 | <0.001 |
Difference between ST and center | −12.56 ± 17.01 (274.84 ± 371.50) | <0.001 ‡ | 0.61 ± 3.26 (14.10 ± 75.34) | 0.145 ‡ | <0.001 |
Characteristics | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|
β (95% CI) | p-Value | β (95% CI) | p-Value | |
Age (years, mean ± SD) | −0.067 (−0.324 to 0.190) | 0.611 | ||
Sex (male) | −6.329 (−13.599 to 0.941) | 0.091 | −4.506 (−10.274 to 1.262) | 0.129 |
Laterality (right) | −0.577 (−7.282 to 6.128) | 0.866 | ||
Systemic disease | ||||
DM | 1.270 (−5.608 to 8.148) | 0.718 | ||
HTN | 3.743 (−2.927 to 10.413) | 0.274 | ||
CVA | 3.390 (−19.711 to 26.491) | 0.774 | ||
Axial length (mm) | −0.554 (−2.161 to 1.053) | 0.501 | ||
Anterior chamber depth (mm) | 1.544 (−6.735 to 9.823) | 0.716 | ||
Baseline ECD (cells/mm2) | ||||
Average * | 0.006 (0.001 to 0.012) | 0.068 | 0.003 (−0.001 to 0.007) | 0.266 |
Center | 0.006 (0.001 to 0.012) | 0.059 | ||
Superior temporal | 0.006 (0.001 to 0.012) | 0.074 | ||
Diagnosis | ||||
Neovascular glaucoma | 4.710 (−1.991 to 11.411) | 0.172 | ||
Primary open-angle glaucoma | 2.816 (−5.324 to 10.956) | 0.499 | ||
Uveitic glaucoma | −12.178 (−20.702 to −3.654) | 0.006 | −5.150 (−12.188 to 1.888) | 0.155 |
Chronic angle-closure glaucoma | 1.462 (−15.061 to 17.985) | 0.863 | ||
Pseudoexfoliation glaucoma | 3.123 (−15.842 to 22.088) | 0.748 | ||
Steroid induced glaucoma | −3.738 (−26.837 to 19.361) | 0.752 | ||
Other secondary glaucoma | 0.328 (−11.628 to 12.284) | 0.957 | ||
Preoperative IOP (mmHg) | 0.104 (−0.180 to 0.388) | 0.306 | ||
Postoperative mean IOP (mmHg) | 1.155(0.285 to 2.025) | 0.011 | 0.547 (−0.163 to 1.257) | 0.135 |
Final IOP (mmHg) | 0.514 (−0.223 to 0.251) | 0.467 | ||
Follow-up (months) | 0.252 (−0.011 to 0.515) | 0.063 | 0.189 (−0.021 to 0.399) | 0.081 |
Postoperative topical CAI | 0.056 (−4.246 to 4.358) | 0.542 | ||
AS-OCT parameters | ||||
Tube length (mm) | −2.088 (−6.949 to 2.773) | 0.402 | ||
Tube-cornea distance (mm) | 14.493 (6.786 to 22.200) | <0.001 | 0.744 (−7.515 to 9.003) | 0.860 |
Tube-cornea angle (degree) | 1.427 (1.060 to 1.794) | <0.001 | 1.254 (0.776 to 1.732) | <0.001 |
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Lee, H.M.; Kim, K.N.; Park, K.S.; Lee, N.H.; Lee, S.B.; Kim, C.-S. Relationship between Tube Parameters and Corneal Endothelial Cell Damage after Ahmed Glaucoma Valve Implantation: A Comparative Study. J. Clin. Med. 2020, 9, 2546. https://doi.org/10.3390/jcm9082546
Lee HM, Kim KN, Park KS, Lee NH, Lee SB, Kim C-S. Relationship between Tube Parameters and Corneal Endothelial Cell Damage after Ahmed Glaucoma Valve Implantation: A Comparative Study. Journal of Clinical Medicine. 2020; 9(8):2546. https://doi.org/10.3390/jcm9082546
Chicago/Turabian StyleLee, Han Min, Kyoung Nam Kim, Kee Sup Park, Nam Ho Lee, Sung Bok Lee, and Chang-Sik Kim. 2020. "Relationship between Tube Parameters and Corneal Endothelial Cell Damage after Ahmed Glaucoma Valve Implantation: A Comparative Study" Journal of Clinical Medicine 9, no. 8: 2546. https://doi.org/10.3390/jcm9082546