Lighting Up the Tumor—Fluorescein-Guided Resection of Gangliogliomas
Abstract
:1. Introduction
2. Experimental Section
2.1. Patients and Pre- and Postoperative Clinical and Radiological Evaluation
2.2. Surgical Protocol
2.3. Preoperative Use of Glucocorticoids
2.4. Intraoperative Fluorescence Characteristics and Side Effects
2.5. Extent of Resection
2.6. Ethical Approval
3. Results
3.1. Fluorescence
3.2. Extent of Resection
3.3. Karnofsky Performance Scale (KPS)
3.4. Adverse Events
3.5. Representative Case
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Pat. | Age | Sex | Location | Presenting Symptom | EOR | FLI | Histology | KPS Pre | KPS Post |
---|---|---|---|---|---|---|---|---|---|
1 | 52 | f | Left frontal | Headache | STR | ++ | Ganglioglioma (WHO grade I) | 100 | 100 |
2 | 21 | f | Left frontal | Seizure | GTR | ++ | Ganglioglioma (WHO grade I) | 100 | 100 |
3 | 32 | f | Left temporal | Headache | GTR | ++ | Ganglioglioma (WHO grade I) | 100 | 100 |
4 | 37 | m | Left temporal | Expressive language disorder | GTR | ++ | Ganglioglioma (WHO grade I) | 100 | 100 |
5 | 19 | f | Right frontal | Seizure | GTR | + | Ganglioglioma (WHO grade I) | 100 | 100 |
6 | 55 | m | Left parieto-occipital | Loss of consciousness | GTR | ++ | Ganglioglioma (WHO grade I) | 100 | 100 |
7 | 3 | f | Medulla oblongata | Trigeminal pain | NTR Biopsy | + | Ganglioglioma (WHO grade I) | 100 | 60 |
8 | 8 | m | Sellar and suprasellar | Visual disturbance, hormonal deficit | STR (i) | + | Ganglioglioma (WHO grade I) | 70 | 70 |
9 | 16 | m | Left frontal | Seizures | GTR | + | Ganglioglioma (WHO grade I) | 100 | 100 |
10 | 78 | f | Left temporal | Expressive language disorder | GTR | ++ | Anaplastic ganglioglioma (WHO grade II) | 90 | 30 |
11 | 20 | f | Right frontal | Seizure | GTR | ++ | Ganglioglioma (WHO grade I) | 90 | 90 |
12 | 17 | f | Left temporal | Seizure, cognitive deficit | GTR | ++ | Ganglioglioma and subependymal giant cell astrocytoma (WHO grade I) | 80 | 80 |
13 | 3 | f | Right temporal | Abnormal head posture | NTR (i) | + | Ganglioglioma (WHO grade I) | 90 | 90 |
14 | 16 | f | Left temporoparietal | Seizure | GTR | + | Ganglioglioma (WHO grade I) | 90 | 80 |
15 | 15 | f | Left parietal | Follow-up in NF 1 | GTR | ++ | Ganglioglioma (WHO grade I) | 100 | 100 |
7 | 4 | f | Multifocal right temporal Biopsy | Follow-up (Patient 7) | Biopsy | ++ | Ganglioglioma (WHO grade I) | 90 | 90 |
16 | 14 | m | Right parietal | Seizure | GTR | ++ | Ganglioglioma (WHO grade I) | 90 | 90 |
17 | 3 | f | Vermis, cerebellar | Ataxia | STR (i) | ++ | Desmoplastic infantile ganglioglioma (WHO grade I) | 80 | 60 |
18 | 23 | f | Cerebellar, vermis, midbrain, pineal | Headache | NTR (i) | + | Ganglioglioma (WHO grade I) | 100 | 70 |
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Höhne, J.; Acerbi, F.; Falco, J.; Akçakaya, M.O.; Schmidt, N.O.; Kiris, T.; de Laurentis, C.; Ferroli, P.; Broggi, M.; Schebesch, K.-M. Lighting Up the Tumor—Fluorescein-Guided Resection of Gangliogliomas. J. Clin. Med. 2020, 9, 2405. https://doi.org/10.3390/jcm9082405
Höhne J, Acerbi F, Falco J, Akçakaya MO, Schmidt NO, Kiris T, de Laurentis C, Ferroli P, Broggi M, Schebesch K-M. Lighting Up the Tumor—Fluorescein-Guided Resection of Gangliogliomas. Journal of Clinical Medicine. 2020; 9(8):2405. https://doi.org/10.3390/jcm9082405
Chicago/Turabian StyleHöhne, Julius, Francesco Acerbi, Jacopo Falco, Mehmet Osman Akçakaya, Nils Ole Schmidt, Talat Kiris, Camilla de Laurentis, Paolo Ferroli, Morgan Broggi, and Karl-Michael Schebesch. 2020. "Lighting Up the Tumor—Fluorescein-Guided Resection of Gangliogliomas" Journal of Clinical Medicine 9, no. 8: 2405. https://doi.org/10.3390/jcm9082405