The Hidden Burden of Severe Asthma: From Patient Perspective to New Opportunities for Clinicians
, Peter John Barnes 2, Salvatore Battaglia 1, Alida Benfante 1, Robert Brown 3, Giorgio Walter Canonica 4, Gaetano Caramori 5, Mario Cazzola 6, Stefano Centanni 7, Antonella Cianferoni 8, Angelo Corsico 9, Giuseppe De Carlo 10, Fabiano Di Marco 11, Mina Gaga 12, Catherine Hawrylowicz 13, Enrico Heffler 4, Maria Gabriella Matera 14, Andrea Matucci 15, Pierluigi Paggiaro 16, Alberto Papi 17, Todor Popov 18, Paola Rogliani 6, Pierachille Santus 19, add
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Toshihiro Shirai
Round 1
Reviewer 1 Report
Comments to the authors:
This paper is well written and provides useful information on clinical practice of severe asthma. However, there are some concerns to be clarified.
Line 284, …with features of mainly neutrophilic inflammation: Please refer to the mixed type inflammation involving both eosinophils and neutrophils.
Line 357: Please check if the sentence is correct.
Line 393, ….they poorly correlated to the severity of the disease: Oscillometry, also known as the FOT, in severe asthma is described very shortly. These should be deleted so as not to confuse the readers. Otherwise, the authors should comment thoroughly with references
Line 609: Please check if the sentence is correct.
Author Response
This paper is well written and provides useful information on clinical practice of severe asthma. However, there are some concerns to be clarified.
Line 284, …with features of mainly neutrophilic inflammation: Please refer to the mixed type inflammation involving both eosinophils and neutrophils.
The Reviewer is right. We have changed the sentence accordingly.
Line 357: Please check if the sentence is correct.
The sentence has been changed as correctly pointed out.
Line 393, ….they poorly correlated to the severity of the disease: Oscillometry, also known as the FOT, in severe asthma is described very shortly. These should be deleted so as not to confuse the readers. Otherwise, the authors should comment thoroughly with references
We have followed the suggestion of the Reviewer and removed the sentence that refers to oscillometry and FOT to avoid confusion for the reader.
Reviewer 2 Report
It is a very nice review article concering severe asthma perspectives. I have short comments on that.
- Line 336, 2AR->beta2AR
- Line 739, it would be better if the authors could add more current outcomes of BT.
Author Response
Line 336, 2AR->beta2AR
The thank the Reviewer for pointing this out. Appropriate change has been made.
Line 739, it would be better if the authors could add more current outcomes of BT.
We have expanded the paragraph has properly requested.
