Hemostatic Changes in Patients with COVID-19: A Meta-Analysis with Meta-Regressions
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources and Searches
2.2. Study Selection
2.3. Data Extraction and Quality Assessment
2.4. Data Synthesis and Analysis
3. Results
3.1. Study Characteristics
3.2. Study Group 1 (Severe COVID-19 vs. Mild COVID-19)
3.3. Study Group 2 (Dead with COVID-19 vs. Survived to COVID-19)
3.4. Publication Bias
3.5. Meta-Regression Analyses
4. Discussion
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Study Group 1—Mild Disease vs. Severe Disease | |||||||||||
Author | N of Patients (n) | Male Gender (%) | Age (Years) | CRP (mg/L) | Diabetes (%) | Hypertension (%) | Reported Outcome | ||||
PT | aPTT | D-Dimer | PLT | FYB | |||||||
Cen Y | 652 | -- | -- | 17.53 | -- | -- | NO | NO | YES | YES | NO |
Chen G | 21 | 81 | 57 | 92 | 14.3 | 23.8 | YES | YES | YES | YES | NO |
Chen R a | 500 | 57.1 | 56 | 38.30 | 11.1 | 27 | YES | YES | YES | YES | NO |
Deng Q | 112 | 50.9 | 62.45 | 88.00 | 17 | 32.1 | NO | NO | YES | NO | NO |
Di Micco P | 67 | 70 | 14.60 | NO | NO | YES | YES | YES | |||
Ding X | 72 | 45.8 | 49.75 | 6.9 | 12.5 | NO | NO | NO | YES | NO | |
Dong Y | 147 | 42.9 | 47.00 | 22.62 | NO | NO | YES | NO | YES | ||
Du RH | 109 | 67.9 | 70.7 | 85.70 | 31.2 | 59.6 | YES | YES | YES | YES | NO |
Duan J | 348 | 52.9 | 45 | 11.29 | 3.2 | 7.8 | YES | YES | YES | YES | YES |
Feng Y | 406 | 56.9 | 52.50 | 24.96 | 10.3 | 23.7 | NO | NO | YES | YES | YES |
Fu J | 75 | 60 | 46.6 | 59.56 | 5.3 | 9.3 | NO | NO | YES | NO | YES |
Gao Y | 43 | 60.5 | 44.4 | 32.2 | -- | -- | YES | YES | YES | NO | YES |
Gong J | 189 | 46.6 | 48.79 | -- | -- | -- | NO | YES | YES | YES | NO |
Guan W | 1099 | 9.1 | 46.4 | -- | 7.4 | 15 | NO | NO | NO | YES | NO |
Han H | 84 | -- | -- | -- | -- | -- | YES | YES | YES | NO | YES |
Huang C | 41 | 73.2 | 49.5 | -- | 19.5 | 14.6 | YES | YES | YES | NO | NO |
Li H | 116 | 56.8 | 62.05 | 54.93 | -- | -- | NO | NO | NO | YES | NO |
Li J a | 75 | 55.97 | 59.50 | 3.14 | -- | 32.84 | YES | YES | YES | YES | YES |
Liang W | 1590 | 57.3 | 48.9 | 34.80 | 8.2 | 16.9 | YES | YES | YES | YES | NO |
Liu F | 134 | 47 | 51.5 | -- | 7.5 | 20.1 | NO | NO | YES | NO | NO |
Liu M | 30 | -- | -- | -- | -- | -- | NO | NO | YES | NO | NO |
Liu QS | 150 | 52.7 | 42.19 | 11.3 | 19.3 | YES | YES | YES | YES | YES | |
Liu X | 112 | -- | 56 | 46 | -- | -- | YES | YES | YES | YES | YES |
Liu Y a | 109 | 54.1 | 54.5 | 33.3 | 11 | 33.9 | NO | NO | YES | NO | YES |
Liu Y b | 76 | 64.5 | 46.50 | -- | -- | -- | YES | YES | YES | NO | YES |
Lv Z | 270 | 49.44 | 59.25 | 47.23 | 9.89 | 20.9 | NO | NO | YES | NO | NO |
Ma J | 37 | 54.1 | 63.25 | -- | -- | -- | NO | NO | YES | YES | NO |
Mao L | 214 | 40.7 | 52.7 | -- | -- | -- | NO | NO | YES | YES | NO |
Medetalibeyoğlu A | 68 | 69.1 | 56.52 | -- | -- | -- | NO | YES | YES | YES | YES |
Middeldorp S | 198 | 65.7 | 60.8 | -- | -- | -- | NO | NO | YES | YES | NO |
Mo P | 155 | 55.5 | 53.9 | 43.9 | 9.7 | 23.9 | NO | NO | YES | YES | NO |
Peng Y | 112 | 47.3 | 58.6 | 49.9 | -- | 83 | YES | YES | NO | NO | NO |
Petrilli CM | 4468 | 60.2 | -- | 102.84 | 33.8 | 60.6 | NO | NO | YES | NO | NO |
Qu R | 30 | -- | 58.9 | -- | -- | -- | NO | NO | NO | YES | NO |
Rastrelli G | 27 | -- | 62.60 | 26.63 | 29.6 | 51.8 | NO | NO | YES | NO | YES |
Shang W | 443 | 49.7 | 55.50 | 23.77 | 14.2 | 29.6 | NO | NO | YES | YES | NO |
Smadja DM | 40 | 56.52 | 110.60 | 20 | 40 | NO | NO | YES | YES | YES | |
Sun S | 116 | 51.7 | 49.50 | -- | -- | -- | NO | NO | NO | YES | NO |
Sun Y | 18 | -- | -- | -- | -- | -- | YES | NO | YES | YES | YES |
To KK | 23 | 56.5 | 59.00 | -- | 17 | 26 | NO | NO | NO | YES | NO |
Wan S | 135 | 54.1 | 47.4 | 37.2 | 8.9 | 9.6 | YES | YES | YES | YES | NO |
Wang CZ | 85 | 52.9 | 59.40 | 43.27 | 11.8 | 25.9 | YES | YES | YES | YES | NO |
Wang D a | 138 | 45.7 | 54.4 | -- | 10.1 | 31.2 | YES | YES | YES | YES | NO |
Wang F | 50 | 57 | 57.11 | 68.88 | -- | -- | NO | NO | YES | NO | NO |
Wang R | 125 | 56.8 | 38.76 | 17.76 | -- | -- | NO | NO | NO | YES | NO |
Wu C | 201 | 63.7 | 52.3 | 55.3 | 10.9 | 19.4 | YES | YES | YES | YES | NO |
Wu J | 280 | 53.93 | 43.12 | 7.33 | -- | -- | YES | YES | YES | YES | NO |
Xie H | 79 | 55.7 | 58.50 | 20.70 | 10.1 | 17.7 | NO | NO | YES | NO | NO |
Xu B | 125 | 55 | 60.88 | 32.69 | -- | 26.7 | YES | NO | YES | NO | NO |
Yang AP | 93 | 62.2 | 46.4 | -- | 22.5 | 24.7 | NO | NO | YES | NO | YES |
Yang F | 52 | 53.8 | 64.50 | 30.80 | -- | -- | NO | NO | YES | NO | NO |
Yang Q | 136 | 48.5 | 55.00 | 42.03 | 14.7 | 27.1 | YES | YES | YES | YES | NO |
Yao Q a | 108 | 39.8 | 49.75 | 13.13 | 4.6 | 14.8 | NO | NO | YES | YES | NO |
Young BE | 18 | 50 | 47.1 | 30.3 | 5.6 | 22.2 | NO | NO | NO | YES | NO |
Zhang G | 221 | 48.9 | 53.88 | -- | 24.4 | 35.8 | YES | YES | YES | YES | NO |
Zhang JJ | 140 | 50.7 | 57.0 | 34.2 | 12.1 | 30 | NO | NO | YES | NO | NO |
Zheng F | 161 | 49.7 | 45.13 | 20.15 | 4.3 | 13.7 | NO | NO | NO | YES | NO |
Zheng Y | 141 | 52.4 | 47.00 | -- | -- | -- | NO | NO | NO | YES | NO |
Zhou Y | 17 | 35.3 | -- | -- | -- | -- | NO | NO | YES | NO | NO |
Zou Y | 303 | 52.1 | 51.2 | -- | -- | -- | YES | YES | YES | NO | YES |
Study Group 2—Deaths vs. Survivors | |||||||||||
Author | N of Patients (n) | Male Gender (%) | Age (Years) | CRP (mg/L) | Diabetes (%) | Hypertension (%) | Reported Outcome | ||||
PT | aPTT | D-Dimer | PLT | FYB | |||||||
Auld S | 217 | 54.8 | 63.75 | 192.00 | 45.6 | 61.7 | NO | NO | YES | NO | NO |
Chen R b | 548 | 57.1 | 56 | 38.3 | 11.1 | 27 | YES | YES | YES | YES | NO |
Chen T | 274 | 62.4 | 58.6 | 61.7 | 17.2 | 33.9 | YES | NO | YES | YES | NO |
Desborough MJR | 66 | 73 | 58.25 | 190.25 | 41 | 45 | NO | NO | YES | YES | YES |
Fan H | 73 | 67.12 | 58.36 | 93.84 | -- | 32.88 | YES | NO | YES | YES | NO |
Huang H | 50 | 46 | 35.6 | 30.64 | -- | -- | YES | YES | YES | YES | YES |
Li J b | 161 | -- | 55.40 | -- | -- | -- | YES | YES | YES | YES | NO |
Li L | 93 | 44 | 51 | 14.80 | -- | 5 | YES | YES | YES | YES | NO |
Li Q | 1449 | 51 | 55.5 | -- | -- | -- | YES | YES | YES | YES | YES |
Lodigiani C | 285 | -- | -- | -- | -- | -- | NO | NO | YES | NO | NO |
Luo X | 298 | 50.3 | 55.75 | 34.03 | 15.1 | 28.9 | NO | NO | YES | YES | NO |
Masetti C | 229 | 64.6 | 60.7 | 8.6 | 18.8 | 38 | NO | NO | YES | YES | YES |
Ruan Q | 150 | 68.0 | 56.5 | 76 | 16.7 | 34.7 | NO | NO | NO | YES | NO |
Tang N | 449 | 59.7 | 65.1 | -- | -- | -- | YES | YES * | YES | YES | YES |
Violi F | 319 | 60.4 | 65.61 | 65.98 | 18.6 | 54.6 | NO | NO | YES | YES | NO |
Wang D b | 107 | 53.3 | 50.75 | 10.3 | 24.3 | YES | YES | YES | YES | NO | |
Wang K | 296 | 47.3 | 47.32 | 15.05 | 10.1 | 14.2 | YES | YES | YES | NO | YES |
Yan Y | 48 | 68.8 | 69.4 | -- | 100 | 50 | YES | YES | YES | YES | YES |
Yang X | 1476 | 52.6 | 57 | -- | -- | -- | YES * | NO | NO | YES | NO |
Yao Q b | 108 | 39.8 | 49.75 | 13.13 | 4.6 | 14.8 | NO | NO | YES | YES | NO |
Zhang F | 53 | 25.8 | -- | 29.14 | -- | -- | YES | YES | YES | YES | YES |
Zhang J | 19 | 57.9 | 68.75 | 106.79 | -- | -- | NO | NO | YES | NO | NO |
Zhang S | 315 | 55.55 | 56 | 39.13 | 13.02 | 24.76 | YES | YES | YES | YES | YES |
Zhao X | 532 | 46.2 | 49.10 | -- | 11.1 | 20.3 | NO | NO | NO | YES | NO |
Zhou F | 191 | 36.1 | 56.7 | -- | 18.8 | 30.4 | YES | NO | YES | YES | NO |
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Di Minno, M.N.D.; Calcaterra, I.; Lupoli, R.; Storino, A.; Spedicato, G.A.; Maniscalco, M.; Di Minno, A.; Ambrosino, P. Hemostatic Changes in Patients with COVID-19: A Meta-Analysis with Meta-Regressions. J. Clin. Med. 2020, 9, 2244. https://doi.org/10.3390/jcm9072244
Di Minno MND, Calcaterra I, Lupoli R, Storino A, Spedicato GA, Maniscalco M, Di Minno A, Ambrosino P. Hemostatic Changes in Patients with COVID-19: A Meta-Analysis with Meta-Regressions. Journal of Clinical Medicine. 2020; 9(7):2244. https://doi.org/10.3390/jcm9072244
Chicago/Turabian StyleDi Minno, Matteo Nicola Dario, Ilenia Calcaterra, Roberta Lupoli, Antonio Storino, Giorgio Alfredo Spedicato, Mauro Maniscalco, Alessandro Di Minno, and Pasquale Ambrosino. 2020. "Hemostatic Changes in Patients with COVID-19: A Meta-Analysis with Meta-Regressions" Journal of Clinical Medicine 9, no. 7: 2244. https://doi.org/10.3390/jcm9072244