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Review

SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches—Insights into Chemical Structure—Biological Activity and Toxicological Screening

1
Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
2
Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
3
“Dr. Victor Babes” Clinical Hospital for Infectious Diseases and Pneumophthisiology, 300310 Timisoara, Romania
4
Faculty of Dental Medicine, “Victor Babes” University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
5
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, 71003 Crete, Greece
*
Authors to whom correspondence should be addressed.
Equal contribution as first authors.
J. Clin. Med. 2020, 9(7), 2084; https://doi.org/10.3390/jcm9072084
Received: 21 May 2020 / Revised: 22 June 2020 / Accepted: 26 June 2020 / Published: 2 July 2020
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic represents the primary public health concern nowadays, and great efforts are made worldwide for efficient management of this crisis. Considerable scientific progress was recorded regarding SARS-CoV-2 infection in terms of genomic structure, diagnostic tools, viral transmission, mechanism of viral infection, symptomatology, clinical impact, and complications, but these data evolve constantly. Up to date, neither an effective vaccine nor SARS-CoV-2 specific antiviral agents have been approved, but significant advances were enlisted in this direction by investigating repurposed approved drugs (ongoing clinical trials) or developing innovative antiviral drugs (preclinical and clinical studies). This review presents a thorough analysis of repurposed drug admitted for compassionate use from a chemical structure—biological activity perspective highlighting the ADME (absorption, distribution, metabolism, and excretion) properties and the toxicophore groups linked to potential adverse effects. A detailed pharmacological description of the novel potential anti-COVID-19 therapeutics was also included. In addition, a comprehensible overview of SARS-CoV-2 infection in terms of general description and structure, mechanism of viral infection, and clinical impact was portrayed. View Full-Text
Keywords: SARS-CoV-2; remdesivir; chloroquine; hydroxychloroquine; lopinavir/ritonavir; convalescent plasma SARS-CoV-2; remdesivir; chloroquine; hydroxychloroquine; lopinavir/ritonavir; convalescent plasma
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MDPI and ACS Style

Dehelean, C.A.; Lazureanu, V.; Coricovac, D.; Mioc, M.; Oancea, R.; Marcovici, I.; Pinzaru, I.; Soica, C.; Tsatsakis, A.M.; Cretu, O. SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches—Insights into Chemical Structure—Biological Activity and Toxicological Screening. J. Clin. Med. 2020, 9, 2084. https://doi.org/10.3390/jcm9072084

AMA Style

Dehelean CA, Lazureanu V, Coricovac D, Mioc M, Oancea R, Marcovici I, Pinzaru I, Soica C, Tsatsakis AM, Cretu O. SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches—Insights into Chemical Structure—Biological Activity and Toxicological Screening. Journal of Clinical Medicine. 2020; 9(7):2084. https://doi.org/10.3390/jcm9072084

Chicago/Turabian Style

Dehelean, Cristina A.; Lazureanu, Voichita; Coricovac, Dorina; Mioc, Marius; Oancea, Roxana; Marcovici, Iasmina; Pinzaru, Iulia; Soica, Codruta; Tsatsakis, Aristidis M.; Cretu, Octavian. 2020. "SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches—Insights into Chemical Structure—Biological Activity and Toxicological Screening" J. Clin. Med. 9, no. 7: 2084. https://doi.org/10.3390/jcm9072084

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