Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals

Weber, Daniela; Kochlik, Bastian; Stuetz, Wolfgang; Dollé, Martijn E. T.; Jansen, Eugène H. J. M.; Grubeck-Loebenstein, Beatrix; Debacq-Chainiaux, Florence; Bernhardt, Jürgen; Gonos, Efstathios S.; Capri, Miriam; Franceschi, Claudio; Sikora, Ewa; Moreno-Villanueva, María; Bürkle, Alexander; Grune, Tilman

doi:10.3390/jcm9072072

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Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals

^1,*

Eugène H. J. M. Jansen

³,

Beatrix Grubeck-Loebenstein

⁴,

Florence Debacq-Chainiaux

⁵,

⁶,

⁷,

⁸,

^8,9,

¹⁰

María Moreno-Villanueva

^11,12,

Alexander Bürkle

¹¹

and

Tilman Grune

Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany

Institute of Nutritional Sciences (140), University of Hohenheim, 70599 Stuttgart, Germany

Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720BA Bilthoven, The Netherlands

⁴

Research Institute for Biomedical Aging Research, University of Innsbruck, 6020 Innsbruck, Austria

⁵

URBC-NARILIS, NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur, 5000 Namur, Belgium

⁶

BioTeSys GmbH, 73728 Esslingen, Germany

⁷

Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 116 34 Athina, Greece

⁸

CIG-Interdepartmental Center “L.Galvani”, DIMES, Department of Experimental, Diagnostic and Specialty Medicine, ALMA MATER STUDIORUM, University of Bologna, 40126 Bologna, Italy

⁹

Department of Applied Mathematics of the Institute of ITMM, National Research Lobachevsky State University of Nizhny Novgorod, 603105 Nizhny Novgorod, Russia

¹⁰

Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland

¹¹

Molecular Toxicology Group, University of Konstanz, 78457 Konstanz, Germany

¹²

Human Performance Research Centre, Department of Sport Science, Box 30, University of Konstanz, 78457 Konstanz, Germany

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J. Clin. Med. 2020, 9(7), 2072; https://doi.org/10.3390/jcm9072072

Received: 12 May 2020 / Revised: 26 June 2020 / Accepted: 28 June 2020 / Published: 1 July 2020

(This article belongs to the Section Epidemiology & Public Health)

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Abstract

The regular use of medication may interfere with micronutrient metabolism on several levels, such as absorption, turnover rate, and tissue distribution, and this might be amplified during aging. This study evaluates the impact of self-reported medication intake on plasma micronutrients in the MARK-AGE Project, a cross-sectional observational study in 2217 subjects (age- and sex-stratified) aged 35–75 years from six European countries that were grouped according to age. Polypharmacy as possible determinant of micronutrient concentrations was assessed using multiple linear regression models adjusted for age-group, dietary fruit, vegetables, and juice intake, and other confounders. Younger participants reported taking fewer drugs than older participants. Inverse associations between medication intake and lutein (−3.31% difference per increase in medication group), β-carotene (−11.44%), α-carotene (−8.50%) and positive associations with retinol (+2.26%), α-tocopherol/cholesterol (+2.89%) and γ-tocopherol/cholesterol (+1.36%) occurred in multiple adjusted regression models. Combined usage of a higher number of medical drugs was associated with poorer status of carotenoids on the one hand and higher plasma concentrations of retinol, α- and γ-tocopherol on the other hand. Our results raise concerns regarding the safety of drug combinations via the significant and surprisingly multifaceted disturbance of the concentrations of relevant micronutrients. View Full-Text

Keywords: medication intake; medical drugs; micronutrients; biomarkers; nutrition; age

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MDPI and ACS Style

Weber, D.; Kochlik, B.; Stuetz, W.; Dollé, M.E.T.; Jansen, E.H.J.M.; Grubeck-Loebenstein, B.; Debacq-Chainiaux, F.; Bernhardt, J.; Gonos, E.S.; Capri, M.; Franceschi, C.; Sikora, E.; Moreno-Villanueva, M.; Bürkle, A.; Grune, T. Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals. J. Clin. Med. 2020, 9, 2072. https://doi.org/10.3390/jcm9072072

AMA Style

Weber D, Kochlik B, Stuetz W, Dollé MET, Jansen EHJM, Grubeck-Loebenstein B, Debacq-Chainiaux F, Bernhardt J, Gonos ES, Capri M, Franceschi C, Sikora E, Moreno-Villanueva M, Bürkle A, Grune T. Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals. Journal of Clinical Medicine. 2020; 9(7):2072. https://doi.org/10.3390/jcm9072072

Chicago/Turabian Style

Weber, Daniela, Bastian Kochlik, Wolfgang Stuetz, Martijn E.T. Dollé, Eugène H.J.M. Jansen, Beatrix Grubeck-Loebenstein, Florence Debacq-Chainiaux, Jürgen Bernhardt, Efstathios S. Gonos, Miriam Capri, Claudio Franceschi, Ewa Sikora, María Moreno-Villanueva, Alexander Bürkle, and Tilman Grune. 2020. "Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals" Journal of Clinical Medicine 9, no. 7: 2072. https://doi.org/10.3390/jcm9072072

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Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals

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