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Open AccessArticle

Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects

1
Neurology Department, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy
2
Psychology Department, Azienda Ospedaliera Ospedali Riuniti Marche Nord, 61121 Pesaro-Fano, Italy
3
Scientific Direction, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy
4
Unit of Geriatric Pharmacoepidemiology and Biostatistics, Italian National Research Center on Aging (IRCCS INRCA), 60124 Ancona, Italy
5
Metabolic Diseases and Diabetology Department, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy
6
Eye Clinic, Polytechnic University of Marche, 60126 Ancona, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(7), 2055; https://doi.org/10.3390/jcm9072055
Received: 11 May 2020 / Revised: 9 June 2020 / Accepted: 24 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Effects of Diabetes on Neurodegenerative and Neurovascular Changes)
Background: Type 2 diabetes (T2D) is correlated to amnestic mild cognitive impairment (aMCI) and to non-amnestic mild cognitive impairment (naMCI). This study evaluated whether the T2D variable characterizes a peculiar cognitive profile in elderly patients. Moreover, it explores the association between glycated hemoglobin levels (HbA1c), T2D duration, insulin and oral hypoglycemic agent treatment, and cognition in elderly diabetic patients. Methods: Detailed neuropsychological battery was used to diagnose MCI subtypes. A total of 39 MCI subjects with T2D (T2D-MCI) and 37 MCI subjects without T2D (ND-MCI), matched for age, educational level, and Mini-Mental State Examination score, were included. Results: ND-MCI performed worse in memory and language domains than T2D-MCI. The amnestic subtype is more frequent among ND-MCI and non-amnestic subtype in T2D-MCI. In T2D-MCI, high HbA1c levels correlate with episodic memory (immediate recall) and T2D duration. Some indexes of episodic memory (immediate recall), attention, and visual-spatial ability correlate with insulin treatment. Conclusions: An association between T2D and non-amnestic MCI is suggested. In the T2D-MCI group, significant associations between insulin treatment and memory (immediate recall), complex figure copy, and attention were found. View Full-Text
Keywords: cognitive functions; mild cognitive impairment; dementia; aging; type 2 diabetes; neuropsychological test; Alzheimer’s disease cognitive functions; mild cognitive impairment; dementia; aging; type 2 diabetes; neuropsychological test; Alzheimer’s disease
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MDPI and ACS Style

Valenza, S.; Paciaroni, L.; Paolini, S.; Bonfigli, A.R.; Di Rosa, M.; Rabini, R.A.; Tortato, E.; Pelliccioni, P.; Pelliccioni, G. Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects. J. Clin. Med. 2020, 9, 2055.

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