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Mitochondria at the Crossroads of Physiology and Pathology

Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, Via Amendola 122/O, 70126 Bari, Italy
J. Clin. Med. 2020, 9(6), 1971; https://doi.org/10.3390/jcm9061971
Received: 19 June 2020 / Accepted: 22 June 2020 / Published: 24 June 2020
(This article belongs to the Special Issue The Rise of Mitochondria in Medicine)
Mitochondria play a crucial role in cell life and death by regulating bioenergetic and biosynthetic pathways. They are able to adapt rapidly to different microenvironmental stressors by accommodating the metabolic and biosynthetic needs of the cell. Mounting evidence places mitochondrial dysfunction at the core of several diseases, notably in the context of pathologies of the cardiovascular and central nervous system. In addition, mutations in some mitochondrial proteins are bona fide cancer drivers. Better understanding of the functions of these multifaceted organelles and their components may finetune our knowledge on the molecular bases of certain diseases and suggest new therapeutic avenues. View Full-Text
Keywords: mitochondria; mitochondrial dysfunction; neurodegenerative diseases; cancer; aging; inflammation; infection; cardiovascular diseases mitochondria; mitochondrial dysfunction; neurodegenerative diseases; cancer; aging; inflammation; infection; cardiovascular diseases
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Moro, L. Mitochondria at the Crossroads of Physiology and Pathology. J. Clin. Med. 2020, 9, 1971.

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