Next Article in Journal
Sialylation of Human Natural Killer (NK) Cells Is Regulated by IL-2
Next Article in Special Issue
Serum Klotho in Living Kidney Donors and Kidney Transplant Recipients: A Meta-Analysis
Previous Article in Journal
Gene Expression Profiling in Fibromyalgia Indicates an Autoimmune Origin of the Disease and Opens New Avenues for Targeted Therapy
Previous Article in Special Issue
Erythropoietin, Fibroblast Growth Factor 23, and Death After Kidney Transplantation
Open AccessArticle

Weekend Effect and in-Hospital Mortality in Elderly Patients with Acute Kidney Injury: A Retrospective Analysis of a National Hospital Database in Italy

1
Clinica Medica Unit, Azienda Ospedaliero-Universitaria, I-44121 Ferrara, Italy
2
Department of Medical Sciences, University of Ferrara, I-44121 Ferrara, Italy
3
Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, I-44121 Ferrara, Italy
4
Neuroscience and Rehabilitation Department, Azienda Ospedaliero-Universitaria, I-44121 Ferrara, Italy
5
Nephrology and Dialysis Unit, Azienda Ospedaliero-Universitaria, I-44121 Ferrara, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(6), 1815; https://doi.org/10.3390/jcm9061815
Received: 7 May 2020 / Revised: 9 June 2020 / Accepted: 9 June 2020 / Published: 11 June 2020
Background: The aim of this study was to relate the weekend (WE) effect and acute kidney injury (AKI) in elderly patients by using the Italian National Hospital Database (NHD). Methods: Hospitalizations with AKI of subjects aged ≥ 65 years from 2000–2015 who were identified by the ICD-9-CM were included. Admissions from Friday to Sunday were considered as WE, while all the other days were weekdays (WD). In-hospital mortality (IHM) was our outcome, and the comorbidity burden was calculated by the modified Elixhauser Index (mEI), based on ICD-9-CM codes. Results: 760,664 hospitalizations were analyzed. Mean age was 80.5 ± 7.8 years and 52.2% were males. Of the studied patients, 9% underwent dialysis treatment, 24.3% were admitted during WE, and IHM was 27.7%. Deceased patients were more frequently comorbid males, with higher age, treated with dialysis more frequently, and had higher admission during WE. WE hospitalizations were more frequent in males, and in older patients with higher mEI. IHM was independently associated with dialysis-dependent AKI (OR 2.711; 95%CI 2.667–2.755, p < 0.001), WE admission (OR 1.113; 95%CI 1.100–1.126, p < 0.001), and mEI (OR 1.056; 95% CI 1.055–1.057, p < 0.001). Discussion: Italian elderly patients admitted during WE with AKI are exposed to a higher risk of IHM, especially if they need dialysis treatment and have high comorbidity burden. View Full-Text
Keywords: acute kidney injury; weekend effect; in-hospital mortality; comorbidity; dialysis; elderly acute kidney injury; weekend effect; in-hospital mortality; comorbidity; dialysis; elderly
MDPI and ACS Style

Fabbian, F.; De Giorgi, A.; Di Simone, E.; Cappadona, R.; Lamberti, N.; Manfredini, F.; Boari, B.; Storari, A.; Manfredini, R. Weekend Effect and in-Hospital Mortality in Elderly Patients with Acute Kidney Injury: A Retrospective Analysis of a National Hospital Database in Italy. J. Clin. Med. 2020, 9, 1815.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop