Next Article in Journal
Eye-Catching Microbes—Polyphasic Analysis of the Microbiota on Microscope Oculars Verifies Their Role as Fomites
Next Article in Special Issue
Managing Bladder Cancer Care during the COVID-19 Pandemic Using a Team-Based Approach
Previous Article in Journal
Serum Zinc Level Is Associated with Frailty in Chronic Liver Diseases
Previous Article in Special Issue
Advancing the Science and Management of Renal Cell Carcinoma: Bridging the Divide between Academic and Community Practices
Open AccessReview

Strategies to Improve Participation of Older Adults in Cancer Research

1
Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA 91010, USA
2
Department of Internal Medicine, Harbor-UCLA Medical Center, Los Angeles, CA 90502, USA
3
Department of Supportive Care Medicine, City of Hope, Duarte, CA 91010, USA
*
Author to whom correspondence should be addressed.
Authors contributed equally.
J. Clin. Med. 2020, 9(5), 1571; https://doi.org/10.3390/jcm9051571
Received: 17 April 2020 / Revised: 15 May 2020 / Accepted: 19 May 2020 / Published: 22 May 2020
Cancer is a disease associated with aging. As the US population ages, the number of older adults with cancer is projected to dramatically increase. Despite this, older adults remain vastly underrepresented in research that sets the standards for cancer treatments and, consequently, clinicians struggle with how to interpret data from clinical trials and apply them to older adults in practice. A combination of system, clinician, and patient barriers bar opportunities for trial participation for many older patients, and strategies are needed to address these barriers at multiple fronts, five of which are offered here. This review highlights the need to (1) broaden eligibility criteria, (2) measure relevant end points, (3) expand standard trial designs, (4) increase resources (e.g., institutional support, interdisciplinary care, and telehealth), and (5) develop targeted interventions (e.g., behavioral interventions to promote patient enrollment). Implementing these solutions requires a substantial investment in engaging and collaborating with community-based practices, where the majority of older patients with cancer receive their care. Multifaceted strategies are needed to ensure that older patients with cancer, across diverse healthcare settings, receive the highest-quality, evidence-based care. View Full-Text
Keywords: geriatric oncology; older adults; cancer clinical trials; recruitment; community; team science geriatric oncology; older adults; cancer clinical trials; recruitment; community; team science
Show Figures

Figure 1

MDPI and ACS Style

Liu, J.; Gutierrez, E.; Tiwari, A.; Padam, S.; Li, D.; Dale, W.; Pal, S.K.; Stewart, D.; Subbiah, S.; Bosserman, L.D.; Presant, C.; Phillips, T.; Yap, K.; Hill, A.; Bhatt, G.; Yeon, C.; Cianfrocca, M.; Yuan, Y.; Mortimer, J.; Sedrak, M.S. Strategies to Improve Participation of Older Adults in Cancer Research. J. Clin. Med. 2020, 9, 1571.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop