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Open AccessReview

Preoperative, Intraoperative and Postoperative Corticosteroid Use as an Adjunctive Treatment for Rhegmatogenous Retinal Detachment

1
Department of Experimental Biomedicine and Clinical Neuroscience, Ophthalmology Section, University of Palermo, 90127 Palermo, Italy
2
Department of Ophthalmology, University of Catania, 95100 Catania, Italy
3
Department of Surgical Sciences, Eye Clinic Section, University of Turin, 10122 Turin, Italy
4
Department of Ophthalmology, Second University of Naples, 80131 Naples, Italy
5
Department of General Ophthalmology, Medical University of Lublin, 20079 Lublin, Poland
6
Faculty of Medical Sciences, Collegium Medicum Cardinal Stefan Wyszyński University, 01815 Warsaw, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(5), 1556; https://doi.org/10.3390/jcm9051556
Received: 7 April 2020 / Revised: 13 May 2020 / Accepted: 14 May 2020 / Published: 21 May 2020
(This article belongs to the Section Ophthalmology)
The treatment for rhegmatogenous retinal detachment (RRD) is surgery, including pars plana vitrectomy (PPV) and scleral buckling (SB). Despite surgical advances, degeneration of the photoreceptors and post-operative complications, such as proliferative vitreoretinopathy (PVR), often occurs as the result of inflammation, preventing complete visual recovery or causing RRD recurrence. There is increasing evidence that in the presence of RRD, the activation of inflammatory processes occurs and the surgery itself induces an inflammatory response. This comprehensive review focuses on the use of different formulations of corticosteroids (CCS), as an adjunctive treatment to surgery, either PPV or SB, for RRD repair. The purpose was to review the efficacy and safety of CCS in improving functional and anatomical outcomes and in preventing postoperative complications. This review is organized according to the timing of CCS administration: preoperative, intraoperative, and postoperative. The evidence reviewed supported the role of the pre-operative use of CCS in the treatment of combined RRD and choroidal detachment (CD), reducing CD height. No solid consensus exists on intraoperative and postoperative use of CCS to treat and prevent postoperative complications. However, a large randomized clinical trial including more than 200 eyes suggested that oral prednisone after surgery decreases the rate of postoperative grade B PVR. View Full-Text
Keywords: rhegmatogenous retinal detachment; vitrectomy; scleral buckling; dexamethasone; triamcinolone; fluocinolone; corticosteroids rhegmatogenous retinal detachment; vitrectomy; scleral buckling; dexamethasone; triamcinolone; fluocinolone; corticosteroids
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Bonfiglio, V.; Reibaldi, M.; Macchi, I.; Fallico, M.; Pizzo, C.; Patane, C.; Russo, A.; Longo, A.; Pizzo, A.; Cillino, G.; Cillino, S.; Vadalà, M.; Rinaldi, M.; Rejdak, R.; Nowomiejska, K.; Toro, M.D.; Avitabile, T.; Ortisi, E. Preoperative, Intraoperative and Postoperative Corticosteroid Use as an Adjunctive Treatment for Rhegmatogenous Retinal Detachment. J. Clin. Med. 2020, 9, 1556.

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