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Open AccessArticle

Specific EEG Encephalopathy Pattern in SARS-CoV-2 Patients

1
Clinical Neurophysiology and Instituto de Investigación Biomédica, Hospital Universitario de La Princesa, C/Diego de León 62, 28006 Madrid, Spain
2
Clinical Neurophysiology, Hospital Universitario de La Princesa, C/Diego de León 62, 28006 Madrid, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(5), 1545; https://doi.org/10.3390/jcm9051545
Received: 22 April 2020 / Revised: 13 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
(This article belongs to the Section Clinical Neurology)
We used quantified electroencephalography (qEEG) to define the features of encephalopathy in patients released from the intensive care unit after severe illness from COVID-19. Artifact-free 120–300 s epoch lengths were visually identified and divided into 1 s windows with 10% overlap. Differential channels were grouped by frontal, parieto-occipital, and temporal lobes. For every channel and window, the power spectrum was calculated and used to compute the area for delta (0–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), and beta (13–30 Hz) bands. Furthermore, Shannon’s spectral entropy (SSE) and synchronization by Pearson’s correlation coefficient (ρ) were computed; cases of patients diagnosed with either infectious toxic encephalopathy (ENC) or post-cardiorespiratory arrest (CRA) encephalopathy were used for comparison. Visual inspection of EEGs of COVID patients showed a near-physiological pattern with scarce anomalies. The distribution of EEG bands was different for the three groups, with COVID midway between distributions of ENC and CRA; specifically, temporal lobes showed different distribution for EEG bands in COVID patients. Besides, SSE was higher and hemispheric connectivity lower for COVID. We objectively identified some numerical EEG features in severely ill COVID patients that can allow positive diagnosis of this encephalopathy. View Full-Text
Keywords: cardiorespiratory arrest; correlation coefficient; fast fourier transform; quantified EEG; spectral entropy cardiorespiratory arrest; correlation coefficient; fast fourier transform; quantified EEG; spectral entropy
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MDPI and ACS Style

Pastor, J.; Vega-Zelaya, L.; Martín Abad, E. Specific EEG Encephalopathy Pattern in SARS-CoV-2 Patients. J. Clin. Med. 2020, 9, 1545.

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