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Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

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Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh 221005, India
2
Department of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové, Czech Republic
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Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal
4
Institute for research and Innovation in Heath (i3S), University of Porto, Rua Alfredo Allen, 4200-135 Porto, Portugal
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(4), 1176; https://doi.org/10.3390/jcm9041176
Received: 23 March 2020 / Revised: 12 April 2020 / Accepted: 14 April 2020 / Published: 19 April 2020
(This article belongs to the Special Issue Bioactive Phytochemicals in Health and Disease)
Vacha (Acorus calamus Linn. (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a comprehensive up-to-date report on its ethnomedicinal use, phytochemistry, and pharmacotherapeutic potential, while identifying potential areas for further research. To date, 145 constituents have been isolated from this herb and identified, including phenylpropanoids, sesquiterpenoids, and monoterpenes. Compelling evidence is suggestive of the biopotential of its various extracts and active constituents in several metabolic and neurological disorders, such as anticonvulsant, antidepressant, antihypertensive, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and anti-obesity effects. The present extensive literature survey is expected to provide insights into the involvement of several signaling pathways and oxidative mechanisms that can mitigate oxidative stress, and other indirect mechanisms modulated by active biomolecules of A. calamus to improve neurological and metabolic disorders. View Full-Text
Keywords: Acorus calamus; ethnomedicinal; phytochemistry; toxicity; pharmacological action; clinical trial; neuroprotective; neurological; metabolic application Acorus calamus; ethnomedicinal; phytochemistry; toxicity; pharmacological action; clinical trial; neuroprotective; neurological; metabolic application
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MDPI and ACS Style

Sharma, V.; Sharma, R.; Gautam, D.S.; Kuca, K.; Nepovimova, E.; Martins, N. Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study. J. Clin. Med. 2020, 9, 1176. https://doi.org/10.3390/jcm9041176

AMA Style

Sharma V, Sharma R, Gautam DS, Kuca K, Nepovimova E, Martins N. Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study. Journal of Clinical Medicine. 2020; 9(4):1176. https://doi.org/10.3390/jcm9041176

Chicago/Turabian Style

Sharma, Vineet, Rohit Sharma, DevNath S. Gautam, Kamil Kuca, Eugenie Nepovimova, and Natália Martins. 2020. "Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study" Journal of Clinical Medicine 9, no. 4: 1176. https://doi.org/10.3390/jcm9041176

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