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Article

Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy

1
Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital and College of Medicine, Taoyuan 33305, Taiwan
2
Stanford University Sleep Medicine Division, Stanford, CA 94063, USA
3
Department of Information Management National Taipei University of Nursing and Health Science, Taipei 11219, Taiwan
4
Department of Craniofacial Research Center, Chang Gung Memorial Hospital and College of Medicine, Taoyuan 33305, Taiwan
5
Department of Otolaryngology and Sleep Center, Chang Gung Memorial Hospital and College of Medicine, Taoyuan 33305, Taiwan
*
Authors to whom correspondence should be addressed.
The first authors: Wei-Chih Chin and Yu-Shu Huang contributed equally to this article.
The corresponding authors: Cheng-Hui Lin and Hsueh-Yu Li contributed equally to this article.
J. Clin. Med. 2020, 9(4), 1028; https://doi.org/10.3390/jcm9041028
Received: 8 March 2020 / Revised: 27 March 2020 / Accepted: 31 March 2020 / Published: 5 April 2020
(This article belongs to the Section Otolaryngology)
Background: Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before and after adenotonsillectomy (T&A), compared with controls. Methods: Children with OSA between age 4 and 12 receiving T&A were prospectively followed. Evaluation before and reevaluation six months after the treatment were done, including polysomnography (PSG), blood tests, and questionnaires. Blood samples were obtained to determine the values of high-sensitivity-C-reactive-protein (HS-CRP); tumor-necrosis-factor-alpha (TNF-α); and interleukin (IL)-1, 6, 10, 12, 17, and 23. We compared the results with an age-matched control group. Results: We included 55 OSA children and 32 controls. Children with OSA presented significant improvement after T&A in complaints, signs, apnea hypopnea index (AHI) (p < 0.001), mean oxygen desaturation index (p < 0.001), and mean oxygen saturation (p = 0.010). Upon entering this study, children with OSA had significantly higher cytokine levels than the controls and significant changes in HS-CRP (p = 0.013), TNF-α (p = 0.057), IL-1β (p = 0.022), IL-10 (p = 0.035), and IL-17 (p = 0.010) after T&A. Children with improved but persistently abnormal AHI did not have all cytokine levels normalized, particularly IL-23 and HS-CRP. Conclusion: Sleep-disordered breathing can persist after T&A and can continue to have a negative inflammatory effect. HS-CRP and IL-23 may serve as blood markers for the persistence of sleep-disordered breathing after T&A. View Full-Text
Keywords: inflammation; interleukins; pediatric obstructive-sleep-apnea; adenotonsillectomy inflammation; interleukins; pediatric obstructive-sleep-apnea; adenotonsillectomy
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MDPI and ACS Style

Huang, Y.-S.; Chin, W.-C.; Guilleminault, C.; Chu, K.-C.; Lin, C.-H.; Li, H.-Y. Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy. J. Clin. Med. 2020, 9, 1028. https://doi.org/10.3390/jcm9041028

AMA Style

Huang Y-S, Chin W-C, Guilleminault C, Chu K-C, Lin C-H, Li H-Y. Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy. Journal of Clinical Medicine. 2020; 9(4):1028. https://doi.org/10.3390/jcm9041028

Chicago/Turabian Style

Huang, Yu-Shu, Wei-Chih Chin, Christian Guilleminault, Kuo-Chung Chu, Cheng-Hui Lin, and Hsueh-Yu Li. 2020. "Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy" Journal of Clinical Medicine 9, no. 4: 1028. https://doi.org/10.3390/jcm9041028

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