Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis
by
Anais Grand 1,2,†, Emmanuelle Rochette 1,2,*,†
, Frederic Dutheil 3, David Gozal 4, Valeria Calcaterra 5, Roberto Berni Canani 6, Nazan Cobanoglu 7, Joep P. M. Derikx 8, Gianluca Terrin 9, Bruno Pereira 10 and Etienne Merlin 1,2,11
Anais Grand 1,2,†, Emmanuelle Rochette 1,2,*,†, Frederic Dutheil 3, David Gozal 4, Valeria Calcaterra 5, Roberto Berni Canani 6, Nazan Cobanoglu 7, Joep P. M. Derikx 8, Gianluca Terrin 9, Bruno Pereira 10 and Etienne Merlin 1,2,11
1
Department of Pediatrics, Clermont Ferrand University Hospital, F-63000 Clermont-Ferrand, France
2
Clermont Auvergne University, INSERM, CIC 1405, CRECHE unit, F-63000 Clermont-Ferrand, France
3
Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Preventive and Occupational Medicine, WittyFit, F-63000 Clermont-Ferrand, France
4
Department of Child Health and Child Health Research Institute, University of Missouri School of Medicine, Columbia, MO 65201, USA
5
Department of Internal Medicine, Pediatric and Adolescent Unit, University of Pavia and Department of the Mother and Child Health, Pediatric Endocrinology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
6
Department of Translational Medical Science and ImmunoNutritionLab at CEINGE Advanced Biotechnologies University “Federico II”, 80131 Naples, Italy
7
Department of Pediatric Pulmonology, Ankara University, Faculty of Medicine, 06590 Ankara, Turkey
8
Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam, 1100 DD Amsterdam, The Netherlands
9
Department of Mother and Child Health, University La Sapienza, 00161 Rome, Italy
10
Department of Biostatistics, Clermont Ferrand University Hospital, F-63000 Clermont-Ferrand, France
11
Clermont Auvergne University, INRA, UMR 1019 UNH, ECREIN, F-63000 Clermont-Ferrand, France
*
Author to whom correspondence should be addressed.
†
Contributed equally to this work.
J. Clin. Med. 2020, 9(3), 857; https://doi.org/10.3390/jcm9030857 (registering DOI)
Received: 21 February 2020 / Revised: 13 March 2020 / Accepted: 16 March 2020 / Published: 20 March 2020
(This article belongs to the Section Endocrinology & Metabolism)
Background: Calprotectin (CP) is a protein complex involved in many inflammatory diseases. Obesity is characterized by low-grade inflammation and elevated circulating levels of calprotectin. However, associations between body mass index (BMI) and calprotectin levels have not been explored in otherwise healthy children. Methods: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed and Cochrane Library database up to July 2019. Healthy children’s blood calprotectin values were extracted, and potential correlations were explored. Results: A total of six studies that included data on 593 healthy children were identified. Median calprotectin value was 900.0 (482.0; 1700) ng·mL−1. Multivariable analysis showed no significant associations with age, sample type (serum vs. plasma), or sex. In contrast, a significant effect of BMI z-score (p < 0.001) emerged. Indeed, a positive correlation between BMI z-score and CP, was detected in girls (R: 0.48; p < 0.001) and boys (R: 0.39; p < 0.001). Conclusion: Calprotectin blood levels correlate with the degree of adiposity in healthy children, but are not affected by age, sex, or sample type (serum or plasma).
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MDPI and ACS Style
Grand, A.; Rochette, E.; Dutheil, F.; Gozal, D.; Calcaterra, V.; Berni Canani, R.; Cobanoglu, N.; Derikx, J.P.M.; Terrin, G.; Pereira, B.; Merlin, E. Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis. J. Clin. Med. 2020, 9, 857.
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