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Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis

1
Department of Pediatrics, Clermont Ferrand University Hospital, F-63000 Clermont-Ferrand, France
2
Clermont Auvergne University, INSERM, CIC 1405, CRECHE unit, F-63000 Clermont-Ferrand, France
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Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Preventive and Occupational Medicine, WittyFit, F-63000 Clermont-Ferrand, France
4
Department of Child Health and Child Health Research Institute, University of Missouri School of Medicine, Columbia, MO 65201, USA
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Department of Internal Medicine, Pediatric and Adolescent Unit, University of Pavia and Department of the Mother and Child Health, Pediatric Endocrinology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
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Department of Translational Medical Science and ImmunoNutritionLab at CEINGE Advanced Biotechnologies University “Federico II”, 80131 Naples, Italy
7
Department of Pediatric Pulmonology, Ankara University, Faculty of Medicine, 06590 Ankara, Turkey
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Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam, 1100 DD Amsterdam, The Netherlands
9
Department of Mother and Child Health, University La Sapienza, 00161 Rome, Italy
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Department of Biostatistics, Clermont Ferrand University Hospital, F-63000 Clermont-Ferrand, France
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Clermont Auvergne University, INRA, UMR 1019 UNH, ECREIN, F-63000 Clermont-Ferrand, France
*
Author to whom correspondence should be addressed.
Contributed equally to this work.
J. Clin. Med. 2020, 9(3), 857; https://doi.org/10.3390/jcm9030857 (registering DOI)
Received: 21 February 2020 / Revised: 13 March 2020 / Accepted: 16 March 2020 / Published: 20 March 2020
(This article belongs to the Section Endocrinology & Metabolism)
Background: Calprotectin (CP) is a protein complex involved in many inflammatory diseases. Obesity is characterized by low-grade inflammation and elevated circulating levels of calprotectin. However, associations between body mass index (BMI) and calprotectin levels have not been explored in otherwise healthy children. Methods: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed and Cochrane Library database up to July 2019. Healthy children’s blood calprotectin values were extracted, and potential correlations were explored. Results: A total of six studies that included data on 593 healthy children were identified. Median calprotectin value was 900.0 (482.0; 1700) ng·mL−1. Multivariable analysis showed no significant associations with age, sample type (serum vs. plasma), or sex. In contrast, a significant effect of BMI z-score (p < 0.001) emerged. Indeed, a positive correlation between BMI z-score and CP, was detected in girls (R: 0.48; p < 0.001) and boys (R: 0.39; p < 0.001). Conclusion: Calprotectin blood levels correlate with the degree of adiposity in healthy children, but are not affected by age, sex, or sample type (serum or plasma). View Full-Text
Keywords: pediatric; S100A8/A9; weight pediatric; S100A8/A9; weight
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Grand, A.; Rochette, E.; Dutheil, F.; Gozal, D.; Calcaterra, V.; Berni Canani, R.; Cobanoglu, N.; Derikx, J.P.M.; Terrin, G.; Pereira, B.; Merlin, E. Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis. J. Clin. Med. 2020, 9, 857.

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