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Review

MSC Based Therapies—New Perspectives for the Injured Lung

1
Department of General Pediatrics and Neonatology, Justus-Liebig-University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Feulgenstrasse 12, 35392 Gießen, Germany
2
Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center (UGMLC), Cardiopulmonary Institute (CPI), German Center for Lung Research (DZL), Aulweg 130, 35392 Giessen, Germany
3
Institute of Virology, Philipps University Marburg, Hans-Meerwein-Strasse 2, 35043 Marburg, Germany
4
Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, German Center for Lung Research (DZL), Ludwigstrasse 43, 61231 Bad Nauheim, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(3), 682; https://doi.org/10.3390/jcm9030682
Received: 11 February 2020 / Revised: 25 February 2020 / Accepted: 28 February 2020 / Published: 3 March 2020
(This article belongs to the Special Issue Mesenchymal Stem/Stromal Cells in Immunity and Disease)
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer from severe pulmonary sequelae over the course of a lifetime. Despite substantial improvements in therapeutic interventions, persistent alleviation of clinical symptoms cannot be offered to most patients affected to date. Despite broad discrepancies in origins and pathomechanisms, the important disease entities all have in common the pulmonary inflammatory response which is central to lung injury and structural abnormalities. Mesenchymal stem cells (MSC) attract particular attention due to their broadly acting anti-inflammatory and regenerative properties. Plenty of preclinical studies provided congruent and convincing evidence that MSC have the therapeutic potential to alleviate lung injuries across ages. These include the disease entities bronchopulmonary dysplasia, asthma and the different forms of acute lung injury and chronic pulmonary diseases in adulthood. While clinical trials are so far restricted to pioneering trials on safety and feasibility, preclinical results point out possibilities to boost the therapeutic efficacy of MSC application and to take advantage of the MSC secretome. The presented review summarizes the most recent advances and highlights joint mechanisms of MSC action across disease entities which provide the basis to timely tackle this global disease burden. View Full-Text
Keywords: mesenchymal stem cells; MSC; chronic lung disease; lung repair; extracellular vesicles; bronchopulmonary dysplasia; asthma; chronic obstructive pulmonary disease; idiopathic pulmonary fibrosis; inflammation; lung injury mesenchymal stem cells; MSC; chronic lung disease; lung repair; extracellular vesicles; bronchopulmonary dysplasia; asthma; chronic obstructive pulmonary disease; idiopathic pulmonary fibrosis; inflammation; lung injury
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MDPI and ACS Style

Behnke, J.; Kremer, S.; Shahzad, T.; Chao, C.-M.; Böttcher-Friebertshäuser, E.; Morty, R.E.; Bellusci, S.; Ehrhardt, H. MSC Based Therapies—New Perspectives for the Injured Lung. J. Clin. Med. 2020, 9, 682. https://doi.org/10.3390/jcm9030682

AMA Style

Behnke J, Kremer S, Shahzad T, Chao C-M, Böttcher-Friebertshäuser E, Morty RE, Bellusci S, Ehrhardt H. MSC Based Therapies—New Perspectives for the Injured Lung. Journal of Clinical Medicine. 2020; 9(3):682. https://doi.org/10.3390/jcm9030682

Chicago/Turabian Style

Behnke, Judith, Sarah Kremer, Tayyab Shahzad, Cho-Ming Chao, Eva Böttcher-Friebertshäuser, Rory E. Morty, Saverio Bellusci, and Harald Ehrhardt. 2020. "MSC Based Therapies—New Perspectives for the Injured Lung" Journal of Clinical Medicine 9, no. 3: 682. https://doi.org/10.3390/jcm9030682

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