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Open AccessArticle

Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study

by 1, 1,2,3,*, 1,2, 4, 1, 1, 1,2, 1,2,5, 1,2 and 3,6,† on behalf of HERCCULE Group
1
CHU Clermont-Ferrand, Pédiatrie, F-63000 Clermont-Ferrand, France
2
Université Clermont Auvergne, INSERM, CIC 1405, Unité CRECHE, F-63000 Clermont-Ferrand, France
3
Université de Toulon, Laboratoire IAPS, F-83041 Toulon, France
4
CHU Clermont-Ferrand, Délégation de la Recherche Clinique et Innovations, F-63000 Clermont-Ferrand, France
5
Université Clermont Auvergne, INRA, UMR 1019 UNH, ECREIN, F-63000 Clermont-Ferrand, France
6
Université Clermont Auvergne, Laboratoire des Adaptations Métaboliques en conditions Physiologiques et Physiopathologiques (AME2P), EA 3533, F-63000 Clermont-Ferrand, France
*
Author to whom correspondence should be addressed.
For a list of the HERCCULE group, see Acknowledgements.
J. Clin. Med. 2020, 9(2), 562; https://doi.org/10.3390/jcm9020562
Received: 24 January 2020 / Revised: 7 February 2020 / Accepted: 16 February 2020 / Published: 19 February 2020
(This article belongs to the Section Oncology)
Background: Leukemia is the most common cancer in pediatrics, with many late effects such as higher risk of dyslipidemia, insulin resistance, obesity, and metabolic syndrome. The objective of this work was to investigate substrate oxidation during submaximal exercise in survivors of childhood acute leukemia. Methods: A total of 20 leukemia survivors and 20 healthy children were matched by sex, age, and Tanner stage. They all took a submaximal incremental exercise test to determine fat and carbohydrate oxidation rates. Results: Cardiorespiratory fitness was significantly lower in leukemia survivors, with lower relative VO2 peaks (p < 0.001), lower heart rate values (p = 0.02), and lower exercise power (p = 0.012), whereas rest metabolism and body mass index did not differ between the two groups. During exercise, upward of heart rate relative to VO2 peak was significantly higher (p < 0.001) in childhood leukemia survivors. We found lower carbohydrate and fat oxidation rates (p = 0.07) in leukemia survivors compared with healthy children, and also a significantly lower relative maximal fat oxidation rate (p = 0.014). Conclusion: Despite impaired physical fitness and metabolic response to exercise, childhood leukemia survivors remained sensitive to physical activity interventions, and could readily adapt to submaximal exercise intensity. View Full-Text
Keywords: acute leukemia; children; metabolism; fat oxidation; physical fitness acute leukemia; children; metabolism; fat oxidation; physical fitness
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MDPI and ACS Style

Pegon, C.; Rochette, E.; Rouel, N.; Pereira, B.; Doré, E.; Isfan, F.; Grèze, V.; Merlin, E.; Kanold, J.; Duché, P., on behalf of HERCCULE Group. Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study. J. Clin. Med. 2020, 9, 562. https://doi.org/10.3390/jcm9020562

AMA Style

Pegon C, Rochette E, Rouel N, Pereira B, Doré E, Isfan F, Grèze V, Merlin E, Kanold J, Duché P on behalf of HERCCULE Group. Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study. Journal of Clinical Medicine. 2020; 9(2):562. https://doi.org/10.3390/jcm9020562

Chicago/Turabian Style

Pegon, Charline; Rochette, Emmanuelle; Rouel, Nadège; Pereira, Bruno; Doré, Eric; Isfan, Florentina; Grèze, Victoria; Merlin, Etienne; Kanold, Justyna; Duché, Pascale on behalf of HERCCULE Group. 2020. "Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study" J. Clin. Med. 9, no. 2: 562. https://doi.org/10.3390/jcm9020562

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