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Open AccessArticle

The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia

1
Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain
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Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, 08830 St. Boi de Llobregat, Spain
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Faculty of Psychology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
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Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain
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Department of Clinical Sciences, School of Medicine, University of Barcelona, 08036 Barcelona, Spain
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Department of Radiology, Quirónsalud Hospital, 50012 Zaragoza, Spain
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Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain
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Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
These authors share senior authorship.
J. Clin. Med. 2020, 9(2), 374; https://doi.org/10.3390/jcm9020374
Received: 13 January 2020 / Accepted: 27 January 2020 / Published: 30 January 2020
(This article belongs to the Section Clinical Psychology)
This study explored the brain structural correlates of psychological flexibility (PF) as measured with the Psychological Inflexibility in Pain Scale (PIPS) in patients with fibromyalgia (FM). Structural magnetic resonance imaging data from 47 FM patients were used to identify Gray Matter Volume (GMV) alterations related to PIPS scores. Brain GMV clusters related to PIPS were then correlated with clinical and cognitive variables to further explore how emerged brain clusters were intertwined with FM symptomatology. Longitudinal changes in PIPS-related brain clusters values were assessed by studying pre–post data from 30 patients (15 allocated to a mindfulness-based stress reduction (MBSR) program and 15 to treatment-as-usual). Changes in PIPS-related brain clusters were also explored in participants showing greater/lower longitudinal changes in PIPS scores. PIPS scores were positively associated with GMV in a bilateral cluster in the ventral part of the bed nucleus of the stria terminalis (BNST). Significant associations between BNST cluster with functional impairment, depressive symptomatology, perceived stress and the nonjudging mindfulness facet were observed. Participants reporting greater pre–post increases in PIPS scores showed greater increases in BNST cluster values. These findings contribute to the understanding on the neurobiological bases of PF in FM and encourage further explorations of the role of the BNST in chronic pain. View Full-Text
Keywords: fibromyalgia; psychological inflexibility; mindfulness; bed nucleus of the stria terminalis; neuroimaging fibromyalgia; psychological inflexibility; mindfulness; bed nucleus of the stria terminalis; neuroimaging
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MDPI and ACS Style

Feliu-Soler, A.; Martínez-Zalacaín, I.; Pérez-Aranda, A.; Borràs, X.; Andrés-Rodríguez, L.; Sanabria-Mazo, J.P.; Fayed, N.; Stephan-Otto, C.; Núñez, C.; Soriano-Mas, C.; Luciano, J.V. The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia. J. Clin. Med. 2020, 9, 374.

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