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Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification

Translational Research Unit, Hospital Universitario Miguel Servet, IIS Aragon, 50009 Zaragoza, Spain
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J. Clin. Med. 2020, 9(12), 4128; https://doi.org/10.3390/jcm9124128
Received: 14 October 2020 / Revised: 14 December 2020 / Accepted: 17 December 2020 / Published: 21 December 2020
(This article belongs to the Special Issue Pancreatic Cancer: Challenges and Breakthroughs)
Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, is an extremely lethal disease due to late diagnosis, aggressiveness and lack of effective therapies. Considering its intrinsic heterogeneity, patient stratification models based on transcriptomic and genomic signatures, with partially overlapping subgroups, have been established. Besides molecular alterations, PDAC tumours show a strong desmoplastic response, resulting in profound metabolic reprogramming involving increased glucose and amino acid consumption, as well as lipid scavenging and biosynthesis. Interestingly, recent works have also revealed the existence of metabolic subtypes with differential prognosis within PDAC, which correlated to defined molecular subclasses in patients: lipogenic subtype correlated with a classical/progenitor signature, while glycolytic tumours associated with the highly aggressive basal/squamous profile. Bioinformatic analyses have demonstrated that the representative genes of each metabolic subtype are up-regulated in PDAC samples and predict patient survival. This suggests a relationship between the genetic signature, metabolic profile, and aggressiveness of the tumour. Considering all this, defining metabolic subtypes represents a clear opportunity for patient stratification considering tumour functional behaviour independently of their mutational background. View Full-Text
Keywords: PDAC; pancreatic cancer; glycolysis; lipid metabolism; classification; stratification PDAC; pancreatic cancer; glycolysis; lipid metabolism; classification; stratification
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MDPI and ACS Style

Espiau-Romera, P.; Courtois, S.; Parejo-Alonso, B.; Sancho, P. Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification. J. Clin. Med. 2020, 9, 4128. https://doi.org/10.3390/jcm9124128

AMA Style

Espiau-Romera P, Courtois S, Parejo-Alonso B, Sancho P. Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification. Journal of Clinical Medicine. 2020; 9(12):4128. https://doi.org/10.3390/jcm9124128

Chicago/Turabian Style

Espiau-Romera, Pilar, Sarah Courtois, Beatriz Parejo-Alonso, and Patricia Sancho. 2020. "Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification" Journal of Clinical Medicine 9, no. 12: 4128. https://doi.org/10.3390/jcm9124128

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