Next Article in Journal
Full Dilatation Caesarean Section and the Risk of Preterm Delivery in a Subsequent Pregnancy: A Historical Cohort Study
Next Article in Special Issue
Radiation-Induced Salivary Gland Dysfunction: Mechanisms, Therapeutics and Future Directions
Previous Article in Journal
Short-Term Outcomes of Polycarbophil and Propionibacterium acnes Lysate Gel after Open Hemorrhoidectomy: A Prospective Cohort Study
Previous Article in Special Issue
Special Issue—“Diseases of the Salivary Glands”
Article

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

1
Department of Emergency and Organ Transplantation—Section of Pathology, University of Bari Aldo Moro, Piazza G. Cesare, 11, 70124 Bari, Italy
2
Department of Emergency and Organ Transplantation—Breast Unit, University of Bari Aldo Moro, Piazza G. Cesare, 11, 70124 Bari, Italy
3
Department of Interdisciplinary Medicine—Section of Odontostomatology, University of Bari Aldo Moro, Piazza G. Cesare, 11, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 3997; https://doi.org/10.3390/jcm9123997
Received: 14 November 2020 / Revised: 5 December 2020 / Accepted: 7 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Diseases of the Salivary Glands)
The association between autoimmune diseases, mostly rheumatoid arthritis, systemic lupus erythematosus, celiac disease and Sjögren syndrome, and lymphoma, has been widely demonstrated by several epidemiologic studies. By a mechanism which has not yet been entirely elucidated, chronic activation/stimulation of the immune system, along with the administration of specific treatments, may lead to the onset of different types of lymphoma in such patients. Specifically, patients affected by Sjögren syndrome may develop lymphomas many years after the original diagnosis. Several epidemiologic, hematologic, and histological features may anticipate the progression from Sjögren syndrome into lymphoma but, to the best of our knowledge, a definite pathogenetic mechanism for such progression is still missing. In fact, while the association between Sjögren syndrome and non-Hodgkin lymphoma, mostly extranodal marginal zone lymphomas and, less often, diffuse large B-cell, is well established, many other variables, such as time of onset, gender predilection, sites of occurrence, subtype of lymphoma, and predictive factors, still remain unclear. We report on a rare case of primary breast lymphoma occurring three years after the diagnosis of Sjögren syndrome in a 57-year-old patient. The diagnostic work-up, including radiograms, core needle biopsy, and histological examination, is discussed, along with emerging data from the recent literature, thus highlighting the usefulness of breast surveillance in Sjögren syndrome patients. View Full-Text
Keywords: autoimmune diseases; Sjögren syndrome; minor salivary glands; B-cell lymphoma; extranodal marginal zone lymphoma; MALT lymphoma; primary breast lymphoma autoimmune diseases; Sjögren syndrome; minor salivary glands; B-cell lymphoma; extranodal marginal zone lymphoma; MALT lymphoma; primary breast lymphoma
Show Figures

Figure 1

MDPI and ACS Style

Ingravallo, G.; Maiorano, E.; Moschetta, M.; Limongelli, L.; Mastropasqua, M.G.; Agazzino, G.F.; De Ruvo, V.; Tarantino, P.; Favia, G.; Capodiferro, S. Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature. J. Clin. Med. 2020, 9, 3997. https://doi.org/10.3390/jcm9123997

AMA Style

Ingravallo G, Maiorano E, Moschetta M, Limongelli L, Mastropasqua MG, Agazzino GF, De Ruvo V, Tarantino P, Favia G, Capodiferro S. Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature. Journal of Clinical Medicine. 2020; 9(12):3997. https://doi.org/10.3390/jcm9123997

Chicago/Turabian Style

Ingravallo, Giuseppe, Eugenio Maiorano, Marco Moschetta, Luisa Limongelli, Mauro G. Mastropasqua, Gisella F. Agazzino, Vincenzo De Ruvo, Paola Tarantino, Gianfranco Favia, and Saverio Capodiferro. 2020. "Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature" Journal of Clinical Medicine 9, no. 12: 3997. https://doi.org/10.3390/jcm9123997

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop