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Open AccessArticle

Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case–Control Study

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Hospital El Tomillar de Sevilla, Servicio Andaluz de Salud (SAS), 41500 Alcalá de Guadaira, Spain
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Centro de Salud Najera, Servicio Rioja Salud, 26300 Najera, Spain
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Facultad de Fisioterapia y Enfermería de Toledo, Universidad de Castilla la Mancha, 45005 Toledo, Spain
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Grupo de Investigación Multidisciplinar en Cuidados (IMCU), Universidad de Castilla la Mancha, 45005 Toledo, Spain
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Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC-GE08), 14004 Córdoba, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 3864; https://doi.org/10.3390/jcm9123864
Received: 7 November 2020 / Revised: 24 November 2020 / Accepted: 26 November 2020 / Published: 27 November 2020
(This article belongs to the Special Issue New Insights and Clinical Management of Thyroid Diseases)
The use of levothyroxine is not always related to the elimination of the symptoms of hypothyroidism. The aim of this study is to compare the health-related quality of life (HRQOL) of a group of hypothyroid women under levothyroxine treatment with that of a group of non-hypothyroid women. Methodology: A case–control study was performed. We used convenience sampling. The case group consisted of 152 levothyroxine-treated hypothyroid women; the control group consisted of 238 women without hypothyroidism disorders. All of the participants were euthyroid according to the clinical practice guidelines. We used as instruments the Short Form-12 questionnaire (SF-12v1) and a sociodemographic questionnaire. Results: Hypothyroid women scored significantly lower in HRQOL in SF-12v1 mental and physical components than the control group (mental component summary: 41.23 ± 12.12 vs. 46.45 ± 10.22, p < 0.001; physical component summary: 49.64 ± 10.16 vs. 54.75 ± 5.76, p < 0.001). body mass index (BMI) and age showed an influence on the physical component (p < 0.001 in both variables). Adjusted for age and BMI, hypothyroidism was still related to worse scores (p < 0.001). Conclusion: Despite being euthyroid, women with hypothyroidism showed a poorer quality of life than women without hypothyroidism. Health professionals need to assess the HRQOL of women with hypothyroidism. Further research on HRQOL and hypothyroidism is needed. View Full-Text
Keywords: hypothyroidism; quality of life; health; women; thyroid hormone hypothyroidism; quality of life; health; women; thyroid hormone
MDPI and ACS Style

Romero-Gómez, B.; Guerrero-Alonso, P.; Carmona-Torres, J.M.; Pozuelo-Carrascosa, D.P.; Laredo-Aguilera, J.A.; Cobo-Cuenca, A.I. Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case–Control Study. J. Clin. Med. 2020, 9, 3864. https://doi.org/10.3390/jcm9123864

AMA Style

Romero-Gómez B, Guerrero-Alonso P, Carmona-Torres JM, Pozuelo-Carrascosa DP, Laredo-Aguilera JA, Cobo-Cuenca AI. Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case–Control Study. Journal of Clinical Medicine. 2020; 9(12):3864. https://doi.org/10.3390/jcm9123864

Chicago/Turabian Style

Romero-Gómez, Benjamín; Guerrero-Alonso, Paula; Carmona-Torres, Juan M.; Pozuelo-Carrascosa, Diana P.; Laredo-Aguilera, José A.; Cobo-Cuenca, Ana I. 2020. "Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case–Control Study" J. Clin. Med. 9, no. 12: 3864. https://doi.org/10.3390/jcm9123864

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