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Article

Changes of Body Weight and Body Composition in Obese Patients with Prader–Willi Syndrome at 3 and 6 Years of Follow-Up: A Retrospective Cohort Study

1
Clinical Epidemiology Unit, Liver Research Center, 34149 Basovizza, Italy
2
Division of Auxology, Istituto Auxologico Italiano, IRCCS, 28824 Verbania, Italy
3
Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, 28824 Verbania, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(11), 3596; https://doi.org/10.3390/jcm9113596
Received: 27 September 2020 / Revised: 5 November 2020 / Accepted: 6 November 2020 / Published: 8 November 2020
(This article belongs to the Section Endocrinology & Metabolism)
Few short-term studies of weight loss have been performed in adult patients with Prader–Willi syndrome (PWS) undergoing metabolic rehabilitation. We performed a retrospective cohort study of 45 adult obese PWS patients undergoing a long-term multidisciplinary metabolic rehabilitation program based on diet and physical activity. Body composition was evaluated by dual-energy X-ray absorptiometry in 36 (80%) patients. The mean (95% CI) weight change was −3.6 (−7.6 to 0.4, p = 0.08) kg at 3 years and −4.6 (−8.5 to −0.8, p = 0.02) kg at 6 years, and that of BMI was −1.7 (−3.4 to 0.1, p = 0.06) kg/m2 at 3 years and −2.1 (−3.8 to −0.4, p = 0.02) kg/m2 at 6 years. A decrease of about 2% in fat mass per unit of body mass was observed, which is in line with the expectations for moderate weight loss. A possibly clinically relevant decrease in total and low-density lipoprotein cholesterol was also observed. These long-term results are important for patients with PWS, which is characterized by severe hyperphagia, behavioral disturbances, and cognitive impairment and is generally considered “resistant” to classical weight loss interventions. View Full-Text
Keywords: Prader–Willi syndrome; cohort study; weight loss; body composition; dual-energy X-ray absorptiometry; resting energy expenditure; indirect calorimetry; metabolic syndrome Prader–Willi syndrome; cohort study; weight loss; body composition; dual-energy X-ray absorptiometry; resting energy expenditure; indirect calorimetry; metabolic syndrome
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MDPI and ACS Style

Bedogni, G.; Grugni, G.; Cicolini, S.; Caroli, D.; Tamini, S.; Sartorio, A. Changes of Body Weight and Body Composition in Obese Patients with Prader–Willi Syndrome at 3 and 6 Years of Follow-Up: A Retrospective Cohort Study. J. Clin. Med. 2020, 9, 3596. https://doi.org/10.3390/jcm9113596

AMA Style

Bedogni G, Grugni G, Cicolini S, Caroli D, Tamini S, Sartorio A. Changes of Body Weight and Body Composition in Obese Patients with Prader–Willi Syndrome at 3 and 6 Years of Follow-Up: A Retrospective Cohort Study. Journal of Clinical Medicine. 2020; 9(11):3596. https://doi.org/10.3390/jcm9113596

Chicago/Turabian Style

Bedogni, Giorgio, Graziano Grugni, Sabrina Cicolini, Diana Caroli, Sofia Tamini, and Alessandro Sartorio. 2020. "Changes of Body Weight and Body Composition in Obese Patients with Prader–Willi Syndrome at 3 and 6 Years of Follow-Up: A Retrospective Cohort Study" Journal of Clinical Medicine 9, no. 11: 3596. https://doi.org/10.3390/jcm9113596

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