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Volume 9
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10.3390/jcm9113412
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Review

B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?

by
Minodora Desmirean
1,2,
Sebastian Rauch
1,
Ancuta Jurj
1,
Sergiu Pasca
1,
Sabina Iluta
1,
Patric Teodorescu
1,
Cristian Berce
3,
Alina-Andreea Zimta
3,
Cristina Turcas
1,
Adrian-Bogdan Tigu
3,
Cristian Moldovan
3,
Irene Paris
2,
Jakob Steinheber
1,
Cedric Richlitzki
1,
Catalin Constantinescu
1,4,
Olafur Eysteinn Sigurjonsson
5,6,
Delia Dima
7,
Bobe Petrushev
3,8 and
Ciprian Tomuleasa
1,7,*
1
Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj Napoca, Romania
2
Department of Pathology, Constantin Papilian Military Hospital, 400124 Cluj Napoca, Romania
3
Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj Napoca, Romania
4
Department of Anesthesia and Intensive Care, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj Napoca, Romania
5
The Blood Bank, Landspitali—The National University Hospital of Iceland, 101 Reykjavik, Iceland
6
School of Science and Engineering, Reykjavik University, 101 Reykjavik, Iceland
7
Department of Hematology, Ion Chiricuta Clinical Cancer Center, 400124 Cluj Napoca, Romania
8
Department of Pathology, Octavian Fodor Regional Institute of Gastroenterology and Hepatology, 400124 Cluj Napoca, Romania
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(11), 3412; https://doi.org/10.3390/jcm9113412
Received: 5 September 2020 / Revised: 15 October 2020 / Accepted: 19 October 2020 / Published: 24 October 2020
(This article belongs to the Special Issue Progresses in Hematopoietic Stem Cell Transplantation and Cellular Therapies)
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Abstract

Malignant lymphomas are a heterogeneous group of malignancies that develop both in nodal and extranodal sites. The different tissues involved and the highly variable clinicopathological characteristics are linked to the association between the lymphoid neoplastic cells and the tissues they infiltrate. The immune system has developed mechanisms to protect the normal tissue from malignant growth. In this review, we aim to explain how T lymphocyte-driven control is linked to tumor development and describe the tumor-suppressive components of the resistant framework. This manuscript brings forward a new insight with regard to intercellular and intracellular signaling, the immune microenvironment, the impact of therapy, and its predictive implications. A better understanding of the key components of the lymphoma environment is important to properly assess the role of both B and T lymphocytes, as well as their interplay, just as two legendary boxers face each other in a heavyweight title final, as was the case of Ali versus Foreman. View Full-Text
Keywords: malignant lymphomas; tumor microenvironment; lymphocyte inter-talk; B lymphocytes; T lymphocytes malignant lymphomas; tumor microenvironment; lymphocyte inter-talk; B lymphocytes; T lymphocytes
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MDPI and ACS Style

Desmirean, M.; Rauch, S.; Jurj, A.; Pasca, S.; Iluta, S.; Teodorescu, P.; Berce, C.; Zimta, A.-A.; Turcas, C.; Tigu, A.-B.; Moldovan, C.; Paris, I.; Steinheber, J.; Richlitzki, C.; Constantinescu, C.; Sigurjonsson, O.E.; Dima, D.; Petrushev, B.; Tomuleasa, C. B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974? J. Clin. Med. 2020, 9, 3412. https://doi.org/10.3390/jcm9113412

AMA Style

Desmirean M, Rauch S, Jurj A, Pasca S, Iluta S, Teodorescu P, Berce C, Zimta A-A, Turcas C, Tigu A-B, Moldovan C, Paris I, Steinheber J, Richlitzki C, Constantinescu C, Sigurjonsson OE, Dima D, Petrushev B, Tomuleasa C. B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974? Journal of Clinical Medicine. 2020; 9(11):3412. https://doi.org/10.3390/jcm9113412

Chicago/Turabian Style

Desmirean, Minodora, Sebastian Rauch, Ancuta Jurj, Sergiu Pasca, Sabina Iluta, Patric Teodorescu, Cristian Berce, Alina-Andreea Zimta, Cristina Turcas, Adrian-Bogdan Tigu, Cristian Moldovan, Irene Paris, Jakob Steinheber, Cedric Richlitzki, Catalin Constantinescu, Olafur E. Sigurjonsson, Delia Dima, Bobe Petrushev, and Ciprian Tomuleasa. 2020. "B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?" Journal of Clinical Medicine 9, no. 11: 3412. https://doi.org/10.3390/jcm9113412

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