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Article

Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry

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Service de Néphrologie-Dialyse-Transplantation, Université d’Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France
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CHU d’Angers, Université d’Angers, INSERM U1232, CRCINA, 49000 Angers, France
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Service de Néphrologie-Dialyse, CH du Mans, 72000 Le Mans, France
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Service de Néphrologie-Dialyse, CH de Cholet, 49300 Cholet, France
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Service de Néphrologie-Dialyse, CH de Laval, 53000 Laval, France
*
Author to whom correspondence should be addressed.
Nicolas Henry and Benoit Brilland contributed equally to this work.
J. Clin. Med. 2020, 9(10), 3177; https://doi.org/10.3390/jcm9103177
Received: 3 September 2020 / Revised: 20 September 2020 / Accepted: 28 September 2020 / Published: 30 September 2020
(This article belongs to the Special Issue Small-Vessel Vasculitis)
(1) Introduction: The incidence of venous thromboembolisms (VTE) has not been extensively analyzed in patients with antineutrophil cytoplasmic antibody (ANCA)-glomerulonephritis (ANCA-GN). Thus, the aim of the present study was to assess the frequency and the risk factors of VTE in patients with ANCA-GN. (2) Methods: Patients from the Maine-Anjou ANCA-associated vasculitis (AAV) registry with a biopsy showing pauci-immune glomerulonephritis were included. VTE events, site, and interval from AAV diagnosis were analyzed. (3) Results: 133 patients fulfilled the inclusion criteria of the study and were analyzed. VTE episodes were diagnosed in 23/133 (17.3%) patients at a median delay of 3 months from ANCA-GN diagnosis. Patients with VTE had lower serum albumin (p = 0.040), were less frequently on statin therapy (p = 0.009) and had less frequently proteinase-3 (PR3)-ANCAs (p = 0.078). Univariate analysis identified higher age (p = 0.022), lower serum albumin (p = 0.030), lack of statin therapy (p = 0.009), and rituximab treatment (p = 0.018) as significant risk factors of VTE. In multivariate analysis, only lack of statin therapy (HR 4.873; p = 0.042) was significantly associated with VTE. (4) Conclusion: Patients with ANCA-GN are at high risk of VTE, especially within the first months following AAV diagnosis. Our results suggest that statin therapy is associated with a lower risk of VTE in ANCA-GN patients. View Full-Text
Keywords: venous thromboembolism; ANCA glomerulonephritis; statins; risk factor venous thromboembolism; ANCA glomerulonephritis; statins; risk factor
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MDPI and ACS Style

Henry, N.; Brilland, B.; Wacrenier, S.; Djema, A.; Garnier, A.S.; Gansey, R.; Coindre, J.-P.; Besson, V.; Duveau, A.; Subra, J.-F.; Cousin, M.; Piccoli, G.B.; Augusto, J.-F. Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry. J. Clin. Med. 2020, 9, 3177. https://doi.org/10.3390/jcm9103177

AMA Style

Henry N, Brilland B, Wacrenier S, Djema A, Garnier AS, Gansey R, Coindre J-P, Besson V, Duveau A, Subra J-F, Cousin M, Piccoli GB, Augusto J-F. Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry. Journal of Clinical Medicine. 2020; 9(10):3177. https://doi.org/10.3390/jcm9103177

Chicago/Turabian Style

Henry, Nicolas, Benoit Brilland, Samuel Wacrenier, Assia Djema, Anne Sophie Garnier, Renaud Gansey, Jean-Philippe Coindre, Virginie Besson, Agnès Duveau, Jean-François Subra, Maud Cousin, Giorgina Barbara Piccoli, and Jean-François Augusto. 2020. "Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry" Journal of Clinical Medicine 9, no. 10: 3177. https://doi.org/10.3390/jcm9103177

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