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The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence

1
Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, Pushchino 142290, Russia
2
Hospital Clinico Research Foundation, INCLIVA Health Research Institute, 46010 Valencia, Spain
3
Pathology Department, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 206; https://doi.org/10.3390/jcm9010206
Received: 16 December 2019 / Revised: 9 January 2020 / Accepted: 10 January 2020 / Published: 12 January 2020
(This article belongs to the Section Clinical Neurology)
Alzheimer’s disease (AD) is a fatal form of dementia of unknown etiology. Although amyloid plaque accumulation in the brain has been the subject of intensive research in disease pathogenesis and anti-amyloid drug development; the continued failures of the clinical trials suggest that amyloids are not a key cause of AD and new approaches to AD investigation and treatment are needed. We propose a new hypothesis of AD development based on metabolic abnormalities in circulating red blood cells (RBCs) that slow down oxygen release from RBCs into brain tissue which in turn leads to hypoxia-induced brain energy crisis; loss of neurons; and progressive atrophy preceding cognitive dysfunction. This review summarizes current evidence for the erythrocytic hypothesis of AD development and provides new insights into the causes of neurodegeneration offering an innovative way to diagnose and treat this systemic disease. View Full-Text
Keywords: Alzheimer’s disease; amyloid β peptides; brain energy crisis; erythrocytic hypothesis; red blood cells; restoration of energy metabolism Alzheimer’s disease; amyloid β peptides; brain energy crisis; erythrocytic hypothesis; red blood cells; restoration of energy metabolism
MDPI and ACS Style

Kosenko, E.; Tikhonova, L.; Alilova, G.; Urios, A.; Montoliu, C. The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence. J. Clin. Med. 2020, 9, 206.

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