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Hemodynamic Predictors for Sepsis-Induced Acute Kidney Injury: A Preliminary Study
Open AccessArticle

Does Beta-Trace Protein (BTP) Outperform Cystatin C as a Diagnostic Marker of Acute Kidney Injury Complicating the Early Phase of Acute Pancreatitis?

1
Department of Anatomy, Jagiellonian University Medical College, 31-034 Krakow, Poland
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Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, Poland
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Surgery Department, The District Hospital, 34-200 Sucha Beskidzka, Poland
4
Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Krakow, Poland
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Department of Surgery, Complex of Health Care Centers in Wadowice, 34-100 Wadowice, Poland
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Diagnostics Department of University Hospital in Krakow, 31-501 Krakow, Poland
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Department of Nephrology, Jagiellonian University Medical College, 31-501 Kraków, Poland
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 205; https://doi.org/10.3390/jcm9010205
Received: 28 November 2019 / Revised: 31 December 2019 / Accepted: 7 January 2020 / Published: 11 January 2020
Acute pancreatitis (AP) belongs to the commonest acute gastrointestinal conditions requiring hospitalization. Acute kidney injury (AKI) often complicates moderately severe and severe AP, leading to increased mortality. Among the laboratory markers proposed for early diagnosis of AKI, few have been studied in AP, including cystatin C and neutrophil gelatinase-associated lipocalin (NGAL). Beta-trace protein (BTP), a low-molecular-weight glycoprotein proposed as an early marker of decreased glomerular filtration, has never been studied in AP. We investigated the diagnostic usefulness of serum BTP for early diagnosis of AKI complicating AP in comparison to previously studied markers. BTP was measured in serum samples collected over the first three days of hospital stay from 73 adult patients admitted within 24 h of mild to severe AP. Thirteen patients (18%) developed AKI in the early phase of AP. Serum BTP was higher in patients who developed AKI, starting from the first day of hospitalization. Strong correlations were observed between BTP and serum cystatin C but not serum or urine NGAL. On admission, BTP positively correlated with endothelial dysfunction. The diagnostic usefulness of BTP for AKI was similar to cystatin C and lower than NGAL. Increased BTP is an early predictor of AKI complicating AP. However, it does not outperform cystatin C or NGAL. View Full-Text
Keywords: beta-trace protein; cystatin C; acute pancreatitis; severity; acute kidney injury beta-trace protein; cystatin C; acute pancreatitis; severity; acute kidney injury
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Wajda, J.; Dumnicka, P.; Sporek, M.; Maziarz, B.; Kolber, W.; Ząbek-Adamska, A.; Ceranowicz, P.; Kuźniewski, M.; Kuśnierz-Cabala, B. Does Beta-Trace Protein (BTP) Outperform Cystatin C as a Diagnostic Marker of Acute Kidney Injury Complicating the Early Phase of Acute Pancreatitis? J. Clin. Med. 2020, 9, 205.

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