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Flow Cytometry-Based Quantification of Neutrophil Extracellular Traps Shows an Association with Hypercoagulation in Septic Shock and Hypocoagulation in Postsurgical Systemic Inflammation—A Proof-of-Concept Study
Open AccessArticle

Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock

1
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
2
Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
3
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
4
Statistics and Data Center, Samsung Medical Center, Seoul 06351, Korea
*
Authors to whom correspondence should be addressed.
Jong Eun Park and Tae Gun Shin contributed equally to this work.
J. Clin. Med. 2020, 9(1), 193; https://doi.org/10.3390/jcm9010193
Received: 18 November 2019 / Revised: 3 January 2020 / Accepted: 7 January 2020 / Published: 10 January 2020
(This article belongs to the Special Issue Sepsis: Current Clinical Practices and New Perspectives)
Sepsis is a common cause of delirium in the intensive care unit (ICU). Recently, vitamin C and thiamine administration has been gaining interest as a potential adjunct therapy for sepsis. We investigated the impact of early vitamin C and thiamine administration on ICU delirium-free days among critically ill patients in septic shock. We performed a single-center, retrospective study of patients who visited the emergency department (ED) from January 2017 to July 2018. We categorized patients into a treatment (received vitamin C and thiamine) and control group. We compared delirium-free days within 14 days after ICU admission using propensity score matching. Of 435 patients with septic shock, we assigned 89 propensity score-matched pairs to the treatment and control groups. The median delirium-free days did not differ between treatment (11, interquartile range [IQR] 5–14 days) and control (12, IQR 6–14 days) groups (p = 0.894). Secondary outcomes were not different between the two groups, including delirium incidence and 28-day mortality. These findings were consistent after subgroup analysis for patients who met the sepsis-3 definition of septic shock. Vitamin C and thiamine administration showed no association with ICU delirium-free days among patients in septic shock. View Full-Text
Keywords: septic shock; sepsis; delirium; vitamin C; thiamine septic shock; sepsis; delirium; vitamin C; thiamine
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Park, J.E.; Shin, T.G.; Jo, I.J.; Jeon, K.; Suh, G.Y.; Park, M.; Won, H.; Chung, C.R.; Hwang, S.Y. Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock. J. Clin. Med. 2020, 9, 193.

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