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Maternal Serum Placental Growth Factor, Soluble Fms-Like Tyrosine Kinase-1, and Soluble Endoglin in Twin Gestations and the Risk of Preeclampsia—A Systematic Review

1
Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, 01-809 Warsaw, Poland
2
Chair and Department of Experimental and Clinical Physiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, 02-106 Warsaw, Poland
3
University Center for Woman and Newborn Health of the Medical University of Warsaw, 02-015 Warsaw, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 183; https://doi.org/10.3390/jcm9010183 (registering DOI)
Received: 21 November 2019 / Revised: 16 December 2019 / Accepted: 7 January 2020 / Published: 9 January 2020
(This article belongs to the Section Obstetrics & Gynecology)
Multiple gestation is one of the key risk factors for the occurrence of preeclampsia (PE). Soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin are molecules involved in the process of angiogenesis with a proven role in the pathogenesis of PE. The aim of the review was to summarize available data on maternal serum levels of the above-mentioned factors and their usefulness in predicting PE in twin pregnancies. Only original research articles written in English were considered eligible. Reviews, chapters, case studies, conference papers, experts’ opinions, editorials, and letters were excluded from the analysis. No publication date limitations were imposed. The systematic literature search using PubMed/MEDLINE, Scopus, Embase, and Cochrane Library databases identified 338 articles, 10 of which were included in the final qualitative analyses. The included studies showed significant differences in maternal serum levels of the discussed factors between women with twin pregnancies with PE and those who did not develop PE, and their promising performance in predicting PE, alone or in combination with other factors. The identification of the most effective algorithms, their prompt introduction to the clinical practice, and further assessment of the real-life performance should become a priority. View Full-Text
Keywords: placental growth factor; serum soluble fms-like tyrosine kinase-1; endoglin; preeclampsia; prediction; twin pregnancy placental growth factor; serum soluble fms-like tyrosine kinase-1; endoglin; preeclampsia; prediction; twin pregnancy
MDPI and ACS Style

Kosinska-Kaczynska, K.; Zgliczynska, M.; Kozlowski, S.; Wicherek, L. Maternal Serum Placental Growth Factor, Soluble Fms-Like Tyrosine Kinase-1, and Soluble Endoglin in Twin Gestations and the Risk of Preeclampsia—A Systematic Review. J. Clin. Med. 2020, 9, 183.

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