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Changes in Metabolic Syndrome Status and Risk of Dementia

Department of Family Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Korea
Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul 06351, Korea
Department of Biostatistics, The Catholic University of Korea, Seoul 06591, Korea
Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, Korea
Department of Economics & Center for Economic & Social Research, University of Southern California, Los Angeles, & RAND Corporation, Santa Monica, CA 90401-3208, USA
Department of Neurology, Seoul National University Bundang Hospital & Seoul National University College of Medicine, Seongnam-si 13620, Korea
Department of Family Medicine, Asan Medical Center, Seoul 05505, Korea
Department of Family Medicine, Seoul National University Hospital, Seoul 03080, Korea
Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 122;
Received: 12 November 2019 / Revised: 17 December 2019 / Accepted: 30 December 2019 / Published: 2 January 2020
(This article belongs to the Section Endocrinology & Metabolism)
This study investigated the effects of changes in metabolic syndrome (MS) status and each component on subsequent dementia occurrence. The study population was participants of a biennial National Health Screening Program in 2009–2010 and 2011–2012 in Korea. Participants were divided into four groups according to change in MS status during the two-year interval screening: sustained normal, worsened (normal to MS), improved (MS to normal), and sustained MS group. Risk of dementia among the groups was estimated from the second screening date to 31 December 2016 using a Cox proportional hazards model. A total of 4,106,590 participants were included. The mean follow-up was 4.9 years. Compared to the sustained normal group, adjusted hazard ratios (aHR) (95% confidence interval) were 1.11 (1.08–1.13) for total dementia, 1.08 (1.05–1.11) for Alzheimer’s disease, and 1.20 (1.13–1.28) for vascular dementia in the worsened group; 1.12 (1.10–1.15), 1.10 (1.07–1.13), and 1.19 (1.12–1.27) for the improved group; and 1.18 (1.16–1.20), 1.13 (1.11–1.15), and 1.38 (1.32–1.44) for the sustained MS group. Normalization of MS lowered the risk of all dementia types; total dementia (aHR 1.18 versus 1.12), Alzheimer’s disease (1.13 versus 1.10), and vascular dementia (1.38 versus 1.19). Among MS components, fasting glucose and blood pressure showed more impact. In conclusion, changes in MS status were associated with the risk of dementia. Strategies to improve MS, especially hyperglycemia and blood pressure, may help to prevent dementia. View Full-Text
Keywords: metabolic syndrome; dementia; hyperglycemia; blood pressure; prevention metabolic syndrome; dementia; hyperglycemia; blood pressure; prevention
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MDPI and ACS Style

Lee, J.E.; Shin, D.W.; Han, K.; Kim, D.; Yoo, J.E.; Lee, J.; Kim, S.; Son, K.Y.; Cho, B.; Kim, M.J. Changes in Metabolic Syndrome Status and Risk of Dementia. J. Clin. Med. 2020, 9, 122.

AMA Style

Lee JE, Shin DW, Han K, Kim D, Yoo JE, Lee J, Kim S, Son KY, Cho B, Kim MJ. Changes in Metabolic Syndrome Status and Risk of Dementia. Journal of Clinical Medicine. 2020; 9(1):122.

Chicago/Turabian Style

Lee, Ji E., Dong W. Shin, Kyungdo Han, Dahye Kim, Jung E. Yoo, Jinkook Lee, SangYun Kim, Ki Y. Son, Belong Cho, and Moon J. Kim. 2020. "Changes in Metabolic Syndrome Status and Risk of Dementia" Journal of Clinical Medicine 9, no. 1: 122.

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