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Review

Point-Of-Care Urine LAM Tests for Tuberculosis Diagnosis: A Status Update

1
FIND, 1202 Geneva, Switzerland
2
International Clinical Research Center, University of Washington, Seattle, WA 98105, USA
3
Institute of Disease Modeling, Bellevue, WA 98005, USA
4
Department of Laboratory Medicine, Boston Children’s Hospital, Boston, MA 02115, USA
5
Division of Tropical Medicine, Center of Infectious Diseases, University of Heidelberg, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 111; https://doi.org/10.3390/jcm9010111
Received: 30 November 2019 / Revised: 24 December 2019 / Accepted: 25 December 2019 / Published: 31 December 2019
(This article belongs to the Special Issue Tuberculosis: Clinical Applications in the Diagnosis and Treatment)
Most diagnostic tests for tuberculosis (TB) rely on sputum samples, which are difficult to obtain and have low sensitivity in immunocompromised patients, patients with disseminated TB, and children, delaying treatment initiation. The World Health Organization (WHO) calls for the development of a rapid, biomarker-based, non-sputum test capable of detecting all forms of TB at the point-of-care to enable immediate treatment initiation. Lipoarabinomannan (LAM) is the only WHO-endorsed TB biomarker that can be detected in urine, an easily collected sample. This status update discusses the characteristics of LAM as a biomarker, describes the performance of first-generation urine LAM tests and reasons for slow uptake, and presents considerations for developing the next generation of more sensitive and impactful tests. Next-generation urine LAM tests have the potential to reach adult and pediatric patients regardless of HIV status or site of infection and facilitate global TB control. Implementation and scale-up of existing LAM tests and development of next-generation assays should be prioritized. View Full-Text
Keywords: Tuberculosis (TB); diagnostics; Lipoarabinomannan (LAM); urinary tests Tuberculosis (TB); diagnostics; Lipoarabinomannan (LAM); urinary tests
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  • Externally hosted supplementary file 1
    Doi: 10.20944/preprints201912.0002.v1
MDPI and ACS Style

Bulterys, M.A.; Wagner, B.; Redard-Jacot, M.; Suresh, A.; Pollock, N.R.; Moreau, E.; Denkinger, C.M.; Drain, P.K.; Broger, T. Point-Of-Care Urine LAM Tests for Tuberculosis Diagnosis: A Status Update. J. Clin. Med. 2020, 9, 111. https://doi.org/10.3390/jcm9010111

AMA Style

Bulterys MA, Wagner B, Redard-Jacot M, Suresh A, Pollock NR, Moreau E, Denkinger CM, Drain PK, Broger T. Point-Of-Care Urine LAM Tests for Tuberculosis Diagnosis: A Status Update. Journal of Clinical Medicine. 2020; 9(1):111. https://doi.org/10.3390/jcm9010111

Chicago/Turabian Style

Bulterys, Michelle A., Bradley Wagner, Maël Redard-Jacot, Anita Suresh, Nira R. Pollock, Emmanuel Moreau, Claudia M. Denkinger, Paul K. Drain, and Tobias Broger. 2020. "Point-Of-Care Urine LAM Tests for Tuberculosis Diagnosis: A Status Update" Journal of Clinical Medicine 9, no. 1: 111. https://doi.org/10.3390/jcm9010111

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