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NK Cell Plasticity in Cancer

by Sizhe Liu 1,†, Payal Dhar 1,† and Jennifer D. Wu 1,2,*
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Robert Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA
Author to whom correspondence should be addressed.
Authors contribute equally.
J. Clin. Med. 2019, 8(9), 1492;
Received: 20 August 2019 / Revised: 11 September 2019 / Accepted: 15 September 2019 / Published: 19 September 2019
Natural killer (NK) cells are critical immune components in controlling tumor growth and dissemination. Given their innate capacity to eliminate tumor cells without prior sensitization, NK-based therapies for cancer are actively pursued pre-clinically and clinically. However, recent data suggest that tumors could induce functional alterations in NK cells, polarizing them to tumor-promoting phenotypes. The potential functional plasticity of NK cells in the context of tumors could lead to undesirable outcomes of NK-cell based therapies. In this review, we will summarize to-date evidence of tumor-associated NK cell plasticity and provide our insights for future investigations and therapy development. View Full-Text
Keywords: NK cells; cancer; plasticity NK cells; cancer; plasticity
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Liu, S.; Dhar, P.; Wu, J.D. NK Cell Plasticity in Cancer. J. Clin. Med. 2019, 8, 1492.

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