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NK Cell Plasticity in Cancer

by Sizhe Liu 1,†, Payal Dhar 1,† and Jennifer D. Wu 1,2,*
1
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
2
Robert Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA
*
Author to whom correspondence should be addressed.
Authors contribute equally.
J. Clin. Med. 2019, 8(9), 1492; https://doi.org/10.3390/jcm8091492
Received: 20 August 2019 / Revised: 11 September 2019 / Accepted: 15 September 2019 / Published: 19 September 2019
Natural killer (NK) cells are critical immune components in controlling tumor growth and dissemination. Given their innate capacity to eliminate tumor cells without prior sensitization, NK-based therapies for cancer are actively pursued pre-clinically and clinically. However, recent data suggest that tumors could induce functional alterations in NK cells, polarizing them to tumor-promoting phenotypes. The potential functional plasticity of NK cells in the context of tumors could lead to undesirable outcomes of NK-cell based therapies. In this review, we will summarize to-date evidence of tumor-associated NK cell plasticity and provide our insights for future investigations and therapy development. View Full-Text
Keywords: NK cells; cancer; plasticity NK cells; cancer; plasticity
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Liu, S.; Dhar, P.; Wu, J.D. NK Cell Plasticity in Cancer. J. Clin. Med. 2019, 8, 1492.

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