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Open AccessArticle

Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease

1
Department of Respiratory Medicine, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands
2
Clinical Chemistry, Canisius-Wilhelmina Hospital, 6532 SZ Nijmegen, The Netherlands
3
Laboratory of Respiratory Diseases, Catholic University Leuven, 3000 Leuven, Belgium
4
CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands
5
Department of Respiratory Medicine, University of Birmingham, Birmingham B15 2TT, UK
6
Department of Respiratory Medicine, Catholic University Leuven, 3000 Leuven, Belgium
7
R&D Group VitaK, Maastricht University, 6229 EV Maastricht, The Netherlands
8
Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, 6532 SZ Nijmegen, The Netherlands
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(8), 1116; https://doi.org/10.3390/jcm8081116
Received: 22 June 2019 / Revised: 25 July 2019 / Accepted: 26 July 2019 / Published: 27 July 2019
Elastin degradation is accelerated in chronic obstructive pulmonary disease (COPD) and is partially regulated by Matrix Gla Protein (MGP), via a vitamin K-dependent pathway. The aim was to assess vitamin K status in COPD as well as associations between vitamin K status, elastin degradation, lung function parameters and mortality. A total of 192 COPD patients and 186 age-matched controls were included. In addition to this, 290 COPD patients from a second independent longitudinal cohort were also included. Vitamin K status was assessed by measuring plasma inactive MGP levels and rates of elastin degradation by measuring plasma desmosine levels. Reduced vitamin K status was found in COPD patients compared to smoking controls (p < 0.0005) and controls who had never smoked (p = 0.001). Vitamin K status was inversely associated with desmosine (cohort 1: p = 0.001; cohort 2: p = 0.004). Only few significant associations between vitamin K status and lung function parameters were found. Mortality was higher in COPD patients within the quartile with the lowest vitamin K status compared to those within the other quartiles (hazard ratio 1.85, 95% confidence interval (CI), 1.21–2.83, p = 0.005). In conclusion, we demonstrated reduced vitamin K status in COPD and an inverse association between vitamin K status and elastin degradation rate. Our results therefore suggest a potential role of vitamin K in COPD pathogenesis. View Full-Text
Keywords: chronic obstructive pulmonary disease; desmosine; elastin degradation; matrix Gla protein; vitamin K chronic obstructive pulmonary disease; desmosine; elastin degradation; matrix Gla protein; vitamin K
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MDPI and ACS Style

Piscaer, I.; van den Ouweland, J.M.W.; Vermeersch, K.; Reynaert, N.L.; Franssen, F.M.E.; Keene, S.; Wouters, E.F.M.; Janssens, W.; Vermeer, C.; Janssen, R. Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease. J. Clin. Med. 2019, 8, 1116. https://doi.org/10.3390/jcm8081116

AMA Style

Piscaer I, van den Ouweland JMW, Vermeersch K, Reynaert NL, Franssen FME, Keene S, Wouters EFM, Janssens W, Vermeer C, Janssen R. Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease. Journal of Clinical Medicine. 2019; 8(8):1116. https://doi.org/10.3390/jcm8081116

Chicago/Turabian Style

Piscaer, Ianthe; van den Ouweland, Jody M.W.; Vermeersch, Kristina; Reynaert, Niki L.; Franssen, Frits M.E.; Keene, Spencer; Wouters, Emiel F.M.; Janssens, Wim; Vermeer, Cees; Janssen, Rob. 2019. "Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease" J. Clin. Med. 8, no. 8: 1116. https://doi.org/10.3390/jcm8081116

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