Next Article in Journal
The Role of the Small Bowel in Unintentional Weight Loss after Treatment of Upper Gastrointestinal Cancers
Previous Article in Journal
Uncoupling Traditional Functionalities of Metastasis: The Parting of Ways with Real-Time Assays
Previous Article in Special Issue
Clinical and Biomarker Characteristics According to Clinical Spectrum of Alzheimer’s Disease (AD) in the Validation Cohort of Korean Brain Aging Study for the Early Diagnosis and Prediction of AD
 
 
Article

Combined Intervention of Physical Activity, Aerobic Exercise, and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study

1
Department of Health Care Science, Dong-A University, Busan 49315, Korea
2
Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan
3
Health Convergence Medicine Research Group, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea
4
Department of Neurology, Seongnam Center of Senior Health and Bobath Memorial Hospital, Gyeonggi-do 13552, Korea
5
Busan Metropolitan Dementia Center, Busan 49201, Korea
6
Department of Neurology, College of Medicine, Dong-A University, Busan 49201, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(7), 940; https://doi.org/10.3390/jcm8070940
Received: 4 May 2019 / Revised: 23 June 2019 / Accepted: 26 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Mild Cognitive Impairment)
This study aimed to investigate the association between a dual-task intervention program and cognitive and physical functions. In a randomized controlled trial, we enrolled 49 individuals with MCI. The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the MMSE and modified Alzheimer’s disease Assessment Scale-Cognitive Subscale (ADAS-Cog), both at baseline and at 3 months follow-up. The program comprised physical activity and behavior modification, aerobic exercise, and a cognitive and exercise combined intervention program. Analysis of the subjects for group-time interactions revealed that the exercise group exhibited a significantly improved ADAS-Cog, working memory, and executive function. Total physical activity levels were associated with improvements in working memory function and the modified ADAS-Cog score, and the associations were stronger for daily moderate intensity activity than for daily step count. The 24-week combined intervention improved cognitive function and physical function in patients with MCI relative to controls. Encouraging participants to perform an additional 10 min of moderate physical activity under supervision, during ongoing intervention, may be more beneficial to prevent cognitive decline and improve exercise adherence. View Full-Text
Keywords: dual-task; randomized controlled trial; dementia; older adults dual-task; randomized controlled trial; dementia; older adults
Show Figures

Figure 1

MDPI and ACS Style

Park, H.; Park, J.H.; Na, H.R.; Hiroyuki, S.; Kim, G.M.; Jung, M.K.; Kim, W.K.; Park, K.W. Combined Intervention of Physical Activity, Aerobic Exercise, and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study. J. Clin. Med. 2019, 8, 940. https://doi.org/10.3390/jcm8070940

AMA Style

Park H, Park JH, Na HR, Hiroyuki S, Kim GM, Jung MK, Kim WK, Park KW. Combined Intervention of Physical Activity, Aerobic Exercise, and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study. Journal of Clinical Medicine. 2019; 8(7):940. https://doi.org/10.3390/jcm8070940

Chicago/Turabian Style

Park, Hyuntae, Jong Hwan Park, Hae Ri Na, Shimada Hiroyuki, Gwon Min Kim, Min Ki Jung, Woo Kyung Kim, and Kyung Won Park. 2019. "Combined Intervention of Physical Activity, Aerobic Exercise, and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study" Journal of Clinical Medicine 8, no. 7: 940. https://doi.org/10.3390/jcm8070940

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop