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Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years

1
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima 734-8551, Japan
2
Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima 734-8551, Japan
3
Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima 732-0815, Japan
4
Hiroshima Prefecture Medical Association, Hiroshima 732-0057, Japan
5
Department of Pathology and Research Laboratory, Welfare Association Onomichi General Hospital, Onomichi, Hiroshima 722-8508, Japan
6
Department of Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima 734-8551, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 566; https://doi.org/10.3390/jcm8050566
Received: 18 March 2019 / Revised: 23 April 2019 / Accepted: 24 April 2019 / Published: 26 April 2019
(This article belongs to the Section Oncology)
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Abstract

Salivary gland neoplasms are uncommon, and their epidemiology in Japan has not been well described. We conducted a retrospective review of salivary gland tumors registered in the Hiroshima Tumor Tissue Registry over a period of 39 years. The subjects were 5015 cases ranging in age from 6 to 97 (mean, 54.3) years old. The incidence of both benign tumors and malignant tumors increased with age until 60–69 years and then declined. Among the 5015 salivary gland neoplasms, 3998 (80%) were benign and 1017 (20%) were malignant. Pleomorphic adenoma (PA) was the most frequent benign tumor (68%), followed by Warthin tumor (26%). Adenoid cystic carcinoma (ACC) (27%) and mucoepidermoid carcinoma (MEC) (26%) were the two most frequent malignant tumors. Characteristically, there was a very low incidence of polymorphous adenocarcinoma in Japan. The average annual age-adjusted incidence rate per 100,000 population was 3.3 for benign tumors and 0.8 for malignant tumors. This is the large-scale multi-institutional analysis to describe the characteristics of salivary gland neoplasms, based on the pathological tissue registry data. We hope that the present data can contribute to early diagnosis and effective treatment of salivary gland tumors and to cancer prevention. View Full-Text
Keywords: salivary gland tumors; Japanese population; epidemiology; histology; time trends salivary gland tumors; Japanese population; epidemiology; histology; time trends
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Sentani, K.; Ogawa, I.; Ozasa, K.; Sadakane, A.; Utada, M.; Tsuya, T.; Kajihara, H.; Yonehara, S.; Takeshima, Y.; Yasui, W. Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years. J. Clin. Med. 2019, 8, 566.

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