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Open AccessArticle

Baroreceptor Sensitivity Predicts Functional Outcome and Complications after Acute Ischemic Stroke

Department of Biological Sciences, National Sun Yet-Sen University, Kaohsiung 80424, Taiwan
Section of Neurology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
Department of Physical Therapy, Shu-Zen Junior College of Medicine and Management, Kaohsiung 82144, Taiwan
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(3), 300;
Received: 28 January 2019 / Revised: 26 February 2019 / Accepted: 27 February 2019 / Published: 3 March 2019
(This article belongs to the Special Issue Autonomic Nervous System: From Bench to Bedside)
Autonomic dysfunctions including impaired baroreflex sensitivity (BRS) can develop after acute ischemic stroke (AIS) and may predispose patients to subsequent cardiovascular adverse events and serve as potential indicators of long-term mortality. This study aimed to determine the potential short-term prognostic significance of BRS after AIS. All patients admitted to Kaohsiung Veterans General Hospital within 72 h after onset of first-ever AIS between April 2008 and December 2012 were enrolled. Autonomic evaluation with continuous 10-minute monitoring of beat-to-beat hemodynamic and intracranial parameters was performed within 1 week after stroke by using the Task Force Monitor and transcranial Doppler. The 176 enrolled AIS patients were divided into high-BRS and low-BRS groups. All but two enrolled patients (who died within 3 months after stroke) attended scheduled follow-ups. The high-BRS group had significantly lower National Institutes of Health Stroke Scale (NIHSS) scores at 1 and 2 weeks after stroke and at discharge; lower modified Rankin scale (mRS) scores 1, 3, 6, and 12 months after stroke; and lower rates of complications and stroke recurrence compared to the low-BRS group. This study provides novel evidence of the utility of BRS to independently predict outcomes after AIS. Furthermore, modifying BRS may hold potential in future applications as a novel therapeutic strategy for acute stroke. View Full-Text
Keywords: acute stroke; baroreflexes; intubation; prognostic factors acute stroke; baroreflexes; intubation; prognostic factors
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Lin, C.-H.; Yen, C.-C.; Hsu, Y.-T.; Chen, H.-H.; Cheng, P.-W.; Tseng, C.-J.; Lo, Y.-K.; Chan, J.Y. Baroreceptor Sensitivity Predicts Functional Outcome and Complications after Acute Ischemic Stroke. J. Clin. Med. 2019, 8, 300.

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